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MTEP

Product Name
MTEP
CAS No.
1186195-60-7
Chemical Name
MTEP
Synonyms
MTEP HCl;3-((2-Methyl-1;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
CBNumber
CB22628565
Molecular Formula
C11H9ClN2S
Formula Weight
236.72056
MOL File
1186195-60-7.mol
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MTEP Property

Melting point:
154-156℃ (isopropanol )
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
color 
Light cream
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$475
Updated
2024/03/01
TRC
Product number
M759900
Product name
MTEPHydrochloride
Packaging
1mg
Price
$50
Updated
2021/12/16
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MTEP Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.

Uses

MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.

in vitro

like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].

in vivo

mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].

IC 50

5 nm

storage

+4°C (desiccate)

References

[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.

MTEP Preparation Products And Raw materials

Raw materials

Preparation Products

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MTEP Suppliers

EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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8447
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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58
ApexBio Technology
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
MedChemExpress
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Email
sales@medchemexpress.com
Country
United States
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Olinax Inc.
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info@olinax.com
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United States
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
Country
United States
ProdList
3597
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1186195-60-7, MTEPRelated Search:


  • 3-((2-Methyl-1
  • 3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP
  • 3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride
  • 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
  • 3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1)
  • MTEP HCl
  • Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride
  • 1186195-60-7