TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
CAS No.: 877399-35-4
Chemical Name: TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
Synonyms: 1-(1-Boc-3-azetidinyl)pyrazole-4-boronic Acid Pinacol Ester;1-Boc-3-[4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine;1-BOC-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine - [T11814];tert-butyl 3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate;tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carb;tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]azetidine-1-carboxylate;tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylat;TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE;1-Azetidinecarboxylic acid,3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-,1,1-dimethylethyl ester
CBNumber: CB22638573
Molecular Formula: C17H28BN3O4
Formula Weight: 349.23
MOL File: 877399-35-4.mol

More

Less

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE Property

Boiling point:: 465.7±35.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.63±0.19(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BOR0011681
Product name: TERT-BUTYL-3-[4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL]AZETIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $452.15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-BE
Product name: tert-Butyl 3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $490
Updated: 2021/12/16

AK Scientific

Product number: Y1753
Product name: 1-BOC-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine
Packaging: 1g
Price: $517
Updated: 2021/12/16

Synthonix

Product number: T11814
Product name: 1-BOC-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine
Purity: 97.0%
Packaging: 5g
Price: $1240
Updated: 2021/12/16

Matrix Scientific

Product number: 118518
Product name: tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
Packaging: 1g
Price: $1498
Updated: 2021/12/16

More

Less

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

877399-34-3

73183-34-3

877399-35-4

Synthesis of tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (2-8): tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate (2-8) was synthesized by dissolving compound 3-(4-bromo-1H-pyrazol-1-yl)tert-butyl azetidine-1-carboxylate (2-8) (225 mg, 0.74 mmol), biboronic acid pinacol ester (2-7) (227 mg, 0.89 mmol) and potassium acetate (247 mg, 2.52 mmol) were dissolved in 3 mL of dimethyl sulfoxide (DMSO) and the reaction mixture was purged with nitrogen for 15 min. Subsequently, dichlorobis(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) (PdCl2(dppf)2-CH2Cl2) (30 mg, 2.52 mmol) was added. The resulting mixture was stirred at 80 °C overnight under nitrogen protection. After completion of the reaction, it was cooled to room temperature and the mixture was filtered through a diatomaceous earth pad and washed well with ethyl acetate. The filtrate was washed sequentially with water (2 x 50 mL) and brine (50 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being petroleum ether: ethyl acetate (3:2). The filtrate was concentrated under reduced pressure to give 250 mg of the target product 2-8 as a clear oil (97% yield).1H NMR (400 MHz, chloroform-d) δ ppm 1.18-1.27 (m, 9H), 1.28-1.34 (m, 6H), 1.41-1.49 (m, 6H), 4.22-4.33 (m, 2H), 4.36 (t, J = 8.59 Hz, 2H), 4.98-5.13 (m, 1H), 7.83 (s, 2H).

References

[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 57-58
[2] Patent: WO2006/21881, 2006, A2. Location in patent: Page/Page column 63; 64
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE Suppliers

China 62 India 1 United States 6 Global 69

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Shanghai ShiXian Chemical Technology Co., Ltd.

Tel: 18681884732
Fax: 021-51632502
Email: 2245256225@qq.com
Country: China
ProdList: 1729
Advantage: 50

Shanghai ChuangYan Chemical Technology Co., Ltd.

Tel: 021-11111111 11111111111
Fax: qq:546919421
Email: 546919421@qq.com
Country: China
ProdList: 3518
Advantage: 55

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Chengdu Aslee Biopharmaceuticals, Inc

Tel: 028-85305008 02885305008
Fax: 4000210878-186
Email: 2306208234@qq.com
Country: China
ProdList: 1006
Advantage: 50

Shanghai Rong Lin Medical Technology Co., Ltd.

Tel: 18602194589
Email: lincy-110@163.com
Country: China
ProdList: 863
Advantage: 58

Chengdu J&B Technology Co., Ltd.

Tel: 028-61186694 15608078506
Fax: 028-61186694
Email: 609128801@qq.com
Country: China
ProdList: 837
Advantage: 55

Tianjin Being Technology Co., Ltd.

Tel: 18622939839
Fax: QQ:343281693
Email: tjby921@163.com
Country: China
ProdList: 884
Advantage: 55

877399-35-4, TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATERelated Search:

TERT-BUTYLBORONIC ACID PINACOL ESTER TERT-BUTYLDIMETHYL(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CYCLOHEX-3-ENYLOXY)SILANE POTASSIUM TERT-BUTYLTRIFLUOROBORATE tert-butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)oxy)silane (TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL 2-(N-Boc-aMinoMethyl)-5-chloropyridine TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE tert-Butyldiphenylsilane TERT-BUTYL PROPIOLATE tert-Butyl N-(3-aminopropyl)-N-methylcarbamate TERT-BUTYLDIMETHYL(2-PROPYNYLOXY)SILANE

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE

1-Boc-3-[4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine

tert-butyl 3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate

1-Azetidinecarboxylic acid,3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-,1,1-dimethylethyl ester

tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylat

tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carb

tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]azetidine-1-carboxylate

1-(1-Boc-3-azetidinyl)pyrazole-4-boronic Acid Pinacol Ester

1-BOC-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]azetidine - [T11814]

877399-35-4