AST-1306
- Product Name
- AST-1306
- CAS No.
- 1050500-29-2
- Chemical Name
- AST-1306
- Synonyms
- AST-6;CS-249;AST-130;AST-1306 (TsOH);AST1306 tosilate;AST-1306 mesylate;AST 1306 tosylate;AST1306; AST 1306;Allitinib tosylate;AST-1306 USP/EP/BP
- CBNumber
- CB22646572
- Molecular Formula
- C31H26ClFN4O5S
- Formula Weight
- 621.0783432
- MOL File
- 1050500-29-2.mol
AST-1306 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29708
- Product name
- AST-1306 (tosylate)
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 29708
- Product name
- AST-1306 (tosylate)
- Packaging
- 25mg
- Price
- $616
- Updated
- 2024/03/01
- Product number
- 29708
- Product name
- AST-1306 (tosylate)
- Packaging
- 5mg
- Price
- $262
- Updated
- 2024/03/01
- Product number
- 29708
- Product name
- AST-1306 (tosylate)
- Packaging
- 10mg
- Price
- $412
- Updated
- 2024/03/01
- Product number
- B1020
- Product name
- AST-1306TsOH
- Packaging
- 10mg
- Price
- $459
- Updated
- 2021/12/16
AST-1306 Chemical Properties,Usage,Production
Uses
Alitinib (AST-1306) is a structural analog of lapatinib, a new quinazoline anti-tumor drug, and a small molecule epidermal growth factor receptor tyrosine kinase inhibitor, which selectively acts on EGFR/ErbB2 /ErbB4 receptor.
Biological Activity
ast-1306 is a selective, irreversible inhibitor of erbb2 and egfr with ic50 values of 0.5nm and 3nm, respectively [1].ast-1306 is designed and synthesized based on the chemical structure of lapatinib. the molecular docking method shows ast-1306 binds to the atp-binding pocket of the kinases and form covalent bind with certain amino acids. ast-1306 can inhibit egfr and erbb2 in a cell-free assay with more than 3000-fold selectivity to other kinases. besides the wild-type egfr, ast-1306 also inhibits egfr mutant t790m/l858r both in a cell-free assay and in hih3t3 cells. the growth of the cells is suppressed by ast-1306 due to the inhibition of the phosphorylation of egfr. it also occurs in some human cancer cells. experiments have proved that ast-1306 notly inhibits the phosphorylation of egfr and erbb2 and subsequently decreases the downstream pathways of these kinases in a549 cells, calu-3 cells and sk-ov-3 cells. moreover, ast-1306 potently inhibits the tumor growth both in erbb2-overexpressing xenograft models and fvb-2/nneu transgenic mouse model [1].
target
ErbB2
References
[1] xie h, lin l, tong l, jiang y, zheng m, chen z, jiang x, zhang x, ren x, qu w, yang y, wan h, chen y, zuo j, jiang h, geng m, ding j. ast1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. plos one. 2011;6(7):e21487.
AST-1306 Preparation Products And Raw materials
Raw materials
Preparation Products
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