ChemicalBook > CAS DataBase List > 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE

8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE

Product Name
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
CAS No.
75704-24-4
Chemical Name
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
Synonyms
WAY 161503;WAY 161503 hydrochlo;WAY 161503 HYDROCHLORIDE;(Rac) WAY 161503,(Rac)WAY161503;1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-;8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
CBNumber
CB2265207
Molecular Formula
C11H11Cl2N3O
Formula Weight
272.13
MOL File
75704-24-4.mol
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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Property

Boiling point:
513.9±50.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
pka
12.09±0.20(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17269
Product name
WAY-161503
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17269
Product name
WAY-161503
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17269
Product name
WAY-161503
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
17269
Product name
WAY-161503
Purity
≥98%
Packaging
50mg
Price
$606
Updated
2024/03/01
Tocris
Product number
1801
Product name
WAY 161503 hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$159
Updated
2021/12/16
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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one is a selective 5-hydroxytryptamine 2C receptor agonist with putative antidepressant like properties. It also blocks and decreases baseline nicotine-induced locomotor activity in rats.

Biological Activity

Potent and selective 5-HT 2C receptor agonist (K i = 4 nM; EC 50 = 12 nM). Antidepressant following systemic administration in vivo .

in vivo

(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082[1].

Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.

IC 50

5-HT2C Receptor: 4 nM (Ki); 5-HT2C Receptor: 12 nM (EC50)

8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE Suppliers

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75704-24-4, 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDERelated Search:

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Aniline hydrochloride Pyridine hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE Wash Buffer (20x), 100 mL WASP (B-9) WAPL (A-7) WATER, ELECTROPHORESIS GRADE WAP (E-8) 1-(3,4-Dichlorophenyl)piperazine 2-Piperazinecarboxamide 7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE 6-Chloro-1,2,3,4-tetrahydro-quinoxaline 1-(4-Chlorophenyl)-2-methylpiperazine

  • 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
  • WAY 161503 HYDROCHLORIDE
  • WAY 161503
  • 1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-
  • WAY 161503 hydrochlo
  • (Rac) WAY 161503,(Rac)WAY161503
  • 75704-24-4
  • C11H12Cl3N3O
  • C11H11Cl2N3OHCl
  • Serotonin receptor