ChemicalBook > CAS DataBase List > bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

Product Name
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
CAS No.
314045-39-1
Chemical Name
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
Synonyms
BPTES;CS-1542;BPTES, 10 mM in DMSO;Glutaminase Inhibitor II;Glutaminase Inhibitor II, BPTES;Glutaminase,inhibit,Inhibitor,BPTES;bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide;bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide;Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide;N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
CBNumber
CB22654238
Molecular Formula
C24H24N6O2S3
Formula Weight
524.68
MOL File
314045-39-1.mol
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bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Property

Density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
9.13±0.50(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
HBFNKZVNDOYJDJ-UHFFFAOYSA-N
SMILES
S(CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1)CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0601
Product name
BPTES
Purity
≥95% (HPLC)
Packaging
5mg
Price
$146
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0601
Product name
BPTES
Purity
≥95% (HPLC)
Packaging
25mg
Price
$544.35
Updated
2025/07/31
Sigma-Aldrich
Product number
5.30030
Product name
Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem
Packaging
10mg
Price
$243
Updated
2025/07/31
Cayman Chemical
Product number
19284
Product name
BPTES
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19284
Product name
BPTES
Purity
≥95%
Packaging
5mg
Price
$86
Updated
2024/03/01
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bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Chemical Properties,Usage,Production

Description

BPTES (314045-39-1) is a potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2.? Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6

Uses

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.

Biochem/physiol Actions

Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.

in vivo

BPTES-NPs (BPTES nanoparticles, 1.2 mg BPTES in 100 μL nanoparticles, i.v.) significantly attenuates tumor growth in the patient-derived pancreatic orthotopic tumor model[1].

storage

Store at -20°C

References

[1] BYRON DELABARRE*. Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor[J]. Biochemistry Biochemistry, 2011, 50 50: 10764-10770. DOI:10.1021/bi201613d
[2] KRUPA SHUKLA. Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors[J]. Journal of Medicinal Chemistry, 2012, 55 23: 10551-10563. DOI:10.1021/jm301191p
[3] ANNE LE. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.[J]. Cell metabolism, 2012, 15 1: 110-121. DOI:10.1016/j.cmet.2011.12.009
[4] YAN XIANG. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.[J]. The Journal of clinical investigation, 2015: 2293-2306. DOI:10.1172/jci75836
[5] JUN-KYU BYUN. Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.[J]. Molecular Cell, 2020: 592-606.e8. DOI:10.1016/j.molcel.2020.10.015
[6] CHRISTOPHER PAN  Jason W L. Targeting metabolism to influence aging[J]. Science, 2021, 371 6526. DOI:10.1126/science.abf6368

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Preparation Products And Raw materials

Raw materials

Preparation Products

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bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Suppliers

China 102 India 1 United Kingdom 1 United States 13 Global 117
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
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17771424646
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shoubull@126.com
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China
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Shanghai kcmd Bio Pharmaceutical Co., Ltd
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13818960522
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525712405@qq.com
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China
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Shanghai Beckham Medical Technology Co., Ltd
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13816613772
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QQ: 12922499
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Chembest Research Laboratories Limited
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021-58180499
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sales@BioChemBest.com
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1-631-485-4226; 16314854226
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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021-55068248
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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cfzhang@aikonchem.com
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Shanghai Famo Bio-chemical Technology Company Ltd.
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021-02136680027 15800370750
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1706640024@qq.com
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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View Lastest Price from bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide manufacturers

Career Henan Chemical Co
Product
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide 314045-39-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-02-18

314045-39-1, bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl SulfideRelated Search:

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  • bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
  • bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide
  • Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide
  • BPTES
  • Glutaminase Inhibitor II, BPTES
  • N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
  • CS-1542
  • Glutaminase Inhibitor II
  • Benzeneacetamide, N,N'-[thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bis-
  • 2-phenyl-N-[5-[2-[2-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]ethylsulfanyl]ethyl]-1,3,4-thiadiazol-2-yl]acetamide
  • 2,2'-(5,5'-(2,2'-thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(azanediyl)bis(1-phenylethanone)
  • N,N'-((Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)
  • Glutaminase,inhibit,Inhibitor,BPTES
  • BPTES, 10 mM in DMSO
  • 314045-39-1