bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

Product Name: bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
CAS No.: 314045-39-1
Chemical Name: bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
Synonyms: BPTES;CS-1542;BPTES, 10 mM in DMSO;Glutaminase Inhibitor II;Glutaminase Inhibitor II, BPTES;Glutaminase,inhibit,Inhibitor,BPTES;bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide;bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide;Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide;N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
CBNumber: CB22654238
Molecular Formula: C24H24N6O2S3
Formula Weight: 524.68
MOL File: 314045-39-1.mol

More

Less

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Property

Density: 1.420±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 9.13±0.50(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey: HBFNKZVNDOYJDJ-UHFFFAOYSA-N
SMILES: S(CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1)CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2934999090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0601
Product name: BPTES
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $156
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0601
Product name: BPTES
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $614
Updated: 2026/03/19

Sigma-Aldrich

Product number: 5.30030
Product name: Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem
Packaging: 10mg
Price: $261
Updated: 2026/03/19

Cayman Chemical

Product number: 19284
Product name: BPTES
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19284
Product name: BPTES
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

More

Less

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Chemical Properties,Usage,Production

Description

BPTES (314045-39-1) is a potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6

Uses

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.

Biochem/physiol Actions

Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.

in vivo

BPTES-NPs (BPTES nanoparticles, 1.2 mg BPTES in 100 μL nanoparticles, i.v.) significantly attenuates tumor growth in the patient-derived pancreatic orthotopic tumor model^[1].

storage

Store at -20°C

References

[1] BYRON DELABARRE*. Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor[J]. Biochemistry Biochemistry, 2011, 50 50: 10764-10770. DOI:10.1021/bi201613d
[2] KRUPA SHUKLA. Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors[J]. Journal of Medicinal Chemistry, 2012, 55 23: 10551-10563. DOI:10.1021/jm301191p
[3] ANNE LE. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.[J]. Cell metabolism, 2012, 15 1: 110-121. DOI:10.1016/j.cmet.2011.12.009
[4] YAN XIANG. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.[J]. The Journal of clinical investigation, 2015: 2293-2306. DOI:10.1172/jci75836
[5] JUN-KYU BYUN. Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.[J]. Molecular Cell, 2020: 592-606.e8. DOI:10.1016/j.molcel.2020.10.015
[6] CHRISTOPHER PAN Jason W L. Targeting metabolism to influence aging[J]. Science, 2021, 371 6526. DOI:10.1126/science.abf6368

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Suppliers

China 100 India 1 United Kingdom 1 United States 13 Global 115

Wuhan Shanhai Zhihe Biotechnology Co., Ltd.

Tel: 17771424646
Email: shoubull@126.com
Country: China
ProdList: 944
Advantage: 58

Shanghai kcmd Bio Pharmaceutical Co., Ltd

Tel: 13818960522
Email: 525712405@qq.com
Country: China
ProdList: 220
Advantage: 58

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2519
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4790
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 5000
Advantage: 60

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17714375163
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19906
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-84699383-8003;025-846993838003-8003 18013301593;18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3293
Advantage: 55

More

Less

View Lastest Price from bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide manufacturers

Career Henan Chemical Co

Product: bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide 314045-39-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-18

314045-39-1, bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl SulfideRelated Search:

Geldanamycin S-Trityl-L-cysteine ZM 336372 Cantharidin

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide

BPTES

Glutaminase Inhibitor II, BPTES

N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

CS-1542

Glutaminase Inhibitor II

Benzeneacetamide, N,N'-[thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bis-

2-phenyl-N-[5-[2-[2-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]ethylsulfanyl]ethyl]-1,3,4-thiadiazol-2-yl]acetamide

2,2'-(5,5'-(2,2'-thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(azanediyl)bis(1-phenylethanone)

N,N'-((Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Glutaminase,inhibit,Inhibitor,BPTES

BPTES, 10 mM in DMSO

N,N'-[Sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide)

N,N'-(5,5'-(thiobis(ethane-2,1-diyl))bis(1,3,4-thiodiazole-5,2-diyl))bis(2-phenylacetamide)

314045-39-1