LMK-235
- Product Name
- LMK-235
- CAS No.
- 1418033-25-6
- Chemical Name
- LMK-235
- Synonyms
- CS-1820;LMK-235;LMK235; LMK 235;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide;Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
- CBNumber
- CB22655624
- Molecular Formula
- C15H22N2O4
- Formula Weight
- 294.35
- MOL File
- 1418033-25-6.mol
LMK-235 Property
- Melting point:
- 135-138°C
- Density
- 1.155±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 9.46±0.20(Predicted)
- color
- white to beige
- InChIKey
- VRYZCEONIWEUAV-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1053
- Product name
- LMK235
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $87.2
- Updated
- 2024/03/01
- Product number
- SML1053
- Product name
- LMK235
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $355
- Updated
- 2024/03/01
- Product number
- 14969
- Product name
- LMK 235
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14969
- Product name
- LMK 235
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 14969
- Product name
- LMK 235
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $127
- Updated
- 2024/03/01
LMK-235 Chemical Properties,Usage,Production
Description
Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression. LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM, respectively) over other HDACs (IC50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively). It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA or trichostatin A . LMK 235 and derivatives inhibit the growth of the malarial parasite P. falciparum at multiple life cycle stages at nanomolar concentrations.
Uses
LMK 235 is a histone deacetylase (HDAC)4 and HDAC5 inhibitor and has shown to have enhanced cytotoxic effects against the human cancer cell lines A2780, Cal27, Kyse510, and MDA-MB231.
Biochem/physiol Actions
LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.
LMK-235 Preparation Products And Raw materials
Raw materials
Preparation Products
LMK-235 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77