ChemicalBook > CAS DataBase List > LMK-235

LMK-235

Product Name
LMK-235
CAS No.
1418033-25-6
Chemical Name
LMK-235
Synonyms
CS-1820;LMK-235;LMK235; LMK 235;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide;Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
CBNumber
CB22655624
Molecular Formula
C15H22N2O4
Formula Weight
294.35
MOL File
1418033-25-6.mol
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LMK-235 Property

Melting point:
135-138°C
Density 
1.155±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
9.46±0.20(Predicted)
color 
white to beige
InChIKey
VRYZCEONIWEUAV-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1053
Product name
LMK235
Purity
≥98% (HPLC)
Packaging
5mg
Price
$87.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1053
Product name
LMK235
Purity
≥98% (HPLC)
Packaging
25mg
Price
$355
Updated
2024/03/01
Cayman Chemical
Product number
14969
Product name
LMK 235
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
14969
Product name
LMK 235
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
14969
Product name
LMK 235
Purity
≥98%
Packaging
10mg
Price
$127
Updated
2024/03/01
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LMK-235 Chemical Properties,Usage,Production

Description

Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression. LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM, respectively) over other HDACs (IC50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively). It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA or trichostatin A . LMK 235 and derivatives inhibit the growth of the malarial parasite P. falciparum at multiple life cycle stages at nanomolar concentrations.

Uses

LMK 235 is a histone deacetylase (HDAC)4 and HDAC5 inhibitor and has shown to have enhanced cytotoxic effects against the human cancer cell lines A2780, Cal27, Kyse510, and MDA-MB231.

Biochem/physiol Actions

LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.

LMK-235 Preparation Products And Raw materials

Raw materials

Preparation Products

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LMK-235 Suppliers

China 82 India 2 United Kingdom 1 United States 17 Global 102
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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2782
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Target molecule Corp.
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857-239-0968
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857-239-8801
Email
service1@targetmol.com
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United States
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2559
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Musechem
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+1-800-259-7612
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+1-800-259-7612
Email
info@musechem.com
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United States
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4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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32165
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
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United States
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6391
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
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+1-+1(833)-552-7181
Email
sales@aladdinsci.com
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United States
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57505
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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38632
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United States Biological
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ApexBio Technology
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Santa Cruz Biotechnology, Inc.
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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United States Biological
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chemicals@usbio.net
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United States
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Combi-Blocks Inc.
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Riedel-de Haen AG
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Selleck Chemicals LLC
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1418033-25-6, LMK-235Related Search:

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  • N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide
  • N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
  • LMK-235
  • CS-1820
  • LMK235; LMK 235
  • Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-
  • 1418033-25-6
  • 1418033-85-6
  • Inhibitors