ChemicalBook > CAS DataBase List > PFI-1

PFI-1

Product Name
PFI-1
CAS No.
1403764-72-6
Chemical Name
PFI-1
Synonyms
PFI-1;CS-709;PFI-1cas;PF-6405761;PFI 1;PFI1;PF-06405761;PFI-1 USP/EP/BP;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PFI-1;PFI-1;PFI 1;PFI1
CBNumber
CB22655765
Molecular Formula
C16H17N3O4S
Formula Weight
347.39
MOL File
1403764-72-6.mol
More
Less

PFI-1 Property

storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to beige
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0352
Product name
PFI-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0352
Product name
PFI-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$393
Updated
2024/03/01
Cayman Chemical
Product number
11155
Product name
PFI-1
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
11155
Product name
PFI-1
Purity
≥98%
Packaging
5mg
Price
$104
Updated
2024/03/01
Cayman Chemical
Product number
11155
Product name
PFI-1
Purity
≥98%
Packaging
10mg
Price
$166
Updated
2024/03/01
More
Less

PFI-1 Chemical Properties,Usage,Production

Description

PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.

Uses

PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.

Definition

ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.

storage

Store at RT

PFI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

View Lastest Price from PFI-1 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
PFI-1 1403764-72-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1403764-72-6, PFI-1Related Search:


  • PFI-1
  • PFI-1 (PF-6405761)
  • PFI-1 (PF-06405761)
  • PFI 1;PFI1
  • CS-709
  • PF-06405761
  • Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
  • 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761)
  • 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide
  • PFI-1;PFI-1;PFI 1;PFI1
  • PF-6405761
  • PFI-1 USP/EP/BP
  • PFI-1cas
  • PFI1 PFI-1 PF-06405761 PF06405761
  • Inhibitor,inhibit,Apoptosis,PFI-1,Autophagy,Epigenetic Reader Domain
  • 1403764-72-6
  • Inhibitors
  • Inhibitor