PFI-1
- Product Name
- PFI-1
- CAS No.
- 1403764-72-6
- Chemical Name
- PFI-1
- Synonyms
- PFI-1;CS-709;PFI-1cas;PF-6405761;PFI 1;PFI1;PF-06405761;PFI-1 USP/EP/BP;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PFI-1;PFI-1;PFI 1;PFI1
- CBNumber
- CB22655765
- Molecular Formula
- C16H17N3O4S
- Formula Weight
- 347.39
- MOL File
- 1403764-72-6.mol
PFI-1 Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0352
- Product name
- PFI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- SML0352
- Product name
- PFI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $393
- Updated
- 2024/03/01
- Product number
- 11155
- Product name
- PFI-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 11155
- Product name
- PFI-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 11155
- Product name
- PFI-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
PFI-1 Chemical Properties,Usage,Production
Description
PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.
Uses
PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.
Definition
ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.
storage
Store at RT
PFI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
PFI-1 Suppliers
View Lastest Price from PFI-1 manufacturers
- Product
- PFI-1 1403764-72-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13