6-BROMO-2-METHOXYNICOTINIC ACID

Product Name: 6-BROMO-2-METHOXYNICOTINIC ACID
CAS No.: 1060806-62-3
Chemical Name: 6-BROMO-2-METHOXYNICOTINIC ACID
Synonyms: 6-BROMO-2-METHOXYNICOTINIC ACID;6-bromo-2-methoxy-pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-bromo-2-methoxy-
CBNumber: CB22658478
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 1060806-62-3.mol

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6-BROMO-2-METHOXYNICOTINIC ACID Property

Boiling point:: 327.0±42.0 °C(Predicted)
Density: 1.713±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.13±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B111740
Product name: 6-Bromo-2-methoxynicotinicAcid
Packaging: 50mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 1358AA
Product name: 6-Bromo-2-methoxynicotinicacid
Packaging: 250mg
Price: $265
Updated: 2021/12/16

Apolloscientific

Product number: OR314013
Product name: 6-Bromo-2-methoxynicotinic acid
Purity: 95%
Packaging: 250mg
Price: $473
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367724
Product name: 6-BROMO-2-METHOXYNICOTINIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.57
Updated: 2021/12/16

Ambeed

Product number: A129688
Product name: 6-Bromo-2-methoxynicotinicacid
Purity: 95%
Packaging: 100mg
Price: $72
Updated: 2021/12/16

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6-BROMO-2-METHOXYNICOTINIC ACID Chemical Properties,Usage,Production

Synthesis

40473-07-2

124-38-9

1060806-62-3

General procedure for the synthesis of 6-bromo-2-methoxycarboxylic acid pyridine from 2-bromo-6-methoxypyridine and carbon dioxide: Preparation of 2-methoxy-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinamide: Step 1: Synthesis of 6-bromo-2-methoxynicotinic acid: A tetrahydrofuran (5 mL) solution of 2,2,6,6-tetramethylpiperidine (0.766 g, 5.32 mmol) was cooled under nitrogen protection to -78°C. A hexane solution of 2.5 M n-butyllithium (2.34 mL, 0.375 g, 5.85 mmol) was slowly added and stirred at -78°C for 30 min. Subsequently, a tetrahydrofuran (5 mL) solution of 2-bromo-6-methoxypyridine (1.00 g, 5.32 mmol) was added dropwise. The reaction mixture was continued to be stirred at -78°C for 1 hour. After that, an excess of dry ice was added to slowly warm the reaction mixture to room temperature for 3 hours. Upon completion of the reaction, water and ethyl acetate were added for layering. The aqueous layer was acidified to pH 4 with hydrochloric acid and then extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give an off-white solid product (0.530 g, 42.9% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm: 2.52 (2H, br.s.), 3.32 (1H, br.s.), 3.90 (1H, d, J = 2.9 Hz), 3.92 (1H, m), 8.03 (1H, d, J = 7.8 Hz).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 60

6-BROMO-2-METHOXYNICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-2-METHOXYNICOTINIC ACID Suppliers

China 54 India 1 United States 3 Global 58

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1060806-62-3