6-BROMO-2-METHOXYNICOTINIC ACID
- Product Name
- 6-BROMO-2-METHOXYNICOTINIC ACID
- CAS No.
- 1060806-62-3
- Chemical Name
- 6-BROMO-2-METHOXYNICOTINIC ACID
- Synonyms
- 6-BROMO-2-METHOXYNICOTINIC ACID;6-bromo-2-methoxy-pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-bromo-2-methoxy-
- CBNumber
- CB22658478
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 1060806-62-3.mol
6-BROMO-2-METHOXYNICOTINIC ACID Property
- Boiling point:
- 327.0±42.0 °C(Predicted)
- Density
- 1.713±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.13±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B111740
- Product name
- 6-Bromo-2-methoxynicotinicAcid
- Packaging
- 50mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 1358AA
- Product name
- 6-Bromo-2-methoxynicotinicacid
- Packaging
- 250mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- OR314013
- Product name
- 6-Bromo-2-methoxynicotinic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $473
- Updated
- 2021/12/16
- Product number
- HCH0367724
- Product name
- 6-BROMO-2-METHOXYNICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.57
- Updated
- 2021/12/16
- Product number
- CM176825
- Product name
- 6-Bromo-2-methoxynicotinicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $561
- Updated
- 2021/12/16
6-BROMO-2-METHOXYNICOTINIC ACID Chemical Properties,Usage,Production
Synthesis
40473-07-2
124-38-9
1060806-62-3
General procedure for the synthesis of 6-bromo-2-methoxycarboxylic acid pyridine from 2-bromo-6-methoxypyridine and carbon dioxide: Preparation of 2-methoxy-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinamide: Step 1: Synthesis of 6-bromo-2-methoxynicotinic acid: A tetrahydrofuran (5 mL) solution of 2,2,6,6-tetramethylpiperidine (0.766 g, 5.32 mmol) was cooled under nitrogen protection to -78°C. A hexane solution of 2.5 M n-butyllithium (2.34 mL, 0.375 g, 5.85 mmol) was slowly added and stirred at -78°C for 30 min. Subsequently, a tetrahydrofuran (5 mL) solution of 2-bromo-6-methoxypyridine (1.00 g, 5.32 mmol) was added dropwise. The reaction mixture was continued to be stirred at -78°C for 1 hour. After that, an excess of dry ice was added to slowly warm the reaction mixture to room temperature for 3 hours. Upon completion of the reaction, water and ethyl acetate were added for layering. The aqueous layer was acidified to pH 4 with hydrochloric acid and then extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give an off-white solid product (0.530 g, 42.9% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm: 2.52 (2H, br.s.), 3.32 (1H, br.s.), 3.90 (1H, d, J = 2.9 Hz), 3.92 (1H, m), 8.03 (1H, d, J = 7.8 Hz).
References
[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 60
6-BROMO-2-METHOXYNICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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