MonoMethyl Dolastatin 10

Product Name: MonoMethyl Dolastatin 10
CAS No.: 203849-91-6
Chemical Name: MonoMethyl Dolastatin 10
Synonyms: MMAD;CS-1368;EOS-60620;DeMethyldolastatin 10;MonoMethylauristatin D;MonoMethyl Dolastatin 10;Demethyldolastatin (MMAD);MMAD (Demethyldolastatin 10;MMAD MonoMethyl Dolastatin 10;MonoMethyl Dolastatin 10 / MMAD
CBNumber: CB22666664
Molecular Formula: C41H66N6O6S
Formula Weight: 771.06
MOL File: 203849-91-6.mol

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MonoMethyl Dolastatin 10 Property

Boiling point:: 906.1±65.0 °C(Predicted)
Density: 1.119±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: Powder
pka: 13.81±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M425405
Product name: MonomethylAuristatinD(MMAD)
Packaging: 5mg
Price: $320
Updated: 2021/12/16

Usbiological

Product number: 456565
Product name: Monomethyl Auristatin D
Packaging: 1mg
Price: $333
Updated: 2021/12/16

ChemScene

Product number: CS-1613
Product name: MMAD
Purity: 99.86%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-1613
Product name: MMAD
Purity: 99.86%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-1613
Product name: MMAD
Purity: 99.86%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

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MonoMethyl Dolastatin 10 Chemical Properties,Usage,Production

Description

Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor. Synonyms: Demethyldolastatin 10; Monomethylauristatin D; MMAD.

Uses

MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.

Biological Activity

mmad is a highly potent inhibitor of tubulin [1].mmad is one of the auristatins, which are used as the drugs of antibody drug conjugates (adcs). in adcs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of mabs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. as a payload of adcs, mmad is used to target the tubulin of the tumor cells. it can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1].additionally, mmad is reported to be used in the production of site-specific antibody drug conjugates (ndcs). in the ndcs, mmad is combined with anti-5t4 antibody or anti-her2 antibody. it is shown that the ndcs demonstrate better efficacy and pharmacokinetics [2].

target

tubulin

References

[1] puja sapra, andrea t hooper, christopher j, o’donnell & hans-peter gerber. investigational antibody drug conjugates for solid tumors. expert opin. investig. drugs. 2011, 20(8):1131-1149.
[2] feng tiana, yingchun lu, anthony manibusan, aaron sellers et al. a general approach to site-specific antibody drug conjugates. pnas. 2014, february, 111(5): 1766-1771.

MonoMethyl Dolastatin 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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MonoMethyl Dolastatin 10 Suppliers

China 91 United States 13 Global 104

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View Lastest Price from MonoMethyl Dolastatin 10 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: MMAD;MonoMethyl Dolastatin 10 203849-91-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: MonoMethyl Dolastatin 10 203849-91-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

203849-91-6, MonoMethyl Dolastatin 10Related Search:

VcMMAD MonoMethylauristatin F McMMAE MC-MMAF McMMAD

CS-1368

DEMETHYLDOLASTATIN 10; MONOMETHYLAURISTATIN D; MONOMETHYL DOLASTATIN 10

N-Methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

EOS-60620

MMAD (Demethyldolastatin 10

Demethyldolastatin (MMAD)

DeMethyldolastatin 10

MMAD

MonoMethyl Dolastatin 10

MonoMethylauristatin D

(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

Thiazole,2-bromo-7-(bromomethyl)-

(S)-2-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-N-(methyl-L-valyl)butanamide

MonoMethyl Dolastatin 10 / MMAD

MMAD MonoMethyl Dolastatin 10

203849-91-6

C41H66N6O6S

ADCs