MonoMethylauristatin F
in vivo- Product Name
- MonoMethylauristatin F
- CAS No.
- 745017-94-1
- Chemical Name
- MonoMethylauristatin F
- Synonyms
- MMAF;MonoMethylauristatin;F(MMAF);Tacrinum;745017-97-1;Methyloratatin F;MonoMethylauristatin F;Thiazole,2-bromo-6-methyl-;MMAF (MonoMethylauristatin F);MonoMethyl Auristatin F | MMAF
- CBNumber
- CB62667922
- Molecular Formula
- C39H65N5O8
- Formula Weight
- 731.96
- MOL File
- 745017-94-1.mol
MonoMethylauristatin F Property
- Boiling point:
- 896.8±65.0 °C(Predicted)
- Density
- 1.116±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- form
- A solid
- pka
- 3.56±0.10(Predicted)
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 30197
- Product name
- MMAF
- Packaging
- 25mg
- Price
- $606
- Updated
- 2024/03/01
- Product number
- 30197
- Product name
- MMAF
- Packaging
- 50mg
- Price
- $1062
- Updated
- 2024/03/01
- Product number
- 30197
- Product name
- MMAF
- Packaging
- 5mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 30197
- Product name
- MMAF
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- M564805
- Product name
- MonomethylAuristatinF
- Packaging
- 25mg
- Price
- $745
- Updated
- 2021/12/16
MonoMethylauristatin F Chemical Properties,Usage,Production
in vivo
The maximum tolerated dose in mice of MMAF (Monomethylauristatin F) (>16 mg/kg) is much higher than MMAF (Monomethylauristatin F) (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.
Description
MMAF (Monomethylauristatin F) is an effective tubulin polymerization inhibitor, used as an anti-tumor drug. MMAF (Monomethylauristatin F) is widely used as the cytotoxic component of antibody-conjugated drugs (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A.
Uses
Monomethyl Auristatin F is an antimicrotubule agent. A potent mitotic inhibitor.
Biological Activity
MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.
Biotechnological Applications
MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
in vitro
MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
MonoMethylauristatin F Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MonoMethylauristatin F manufacturers
- Product
- Monomethyl auristatin F 745017-94-1
- Price
- US $20.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 5KG
- Release date
- 2023-06-13
- Product
- MonoMethylauristatin F 745017-94-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-05-22
- Product
- MMAF; Monomethylauristatin F 745017-94-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11