MonoMethyl Dolastatin 10
- Product Name
- MonoMethyl Dolastatin 10
- CAS No.
- 203849-91-6
- Chemical Name
- MonoMethyl Dolastatin 10
- Synonyms
- MMAD;CS-1368;EOS-60620;MonoMe Auristatin D;DeMethyldolastatin 10;MonoMethylauristatin D;MonoMethyl Dolastatin 10;Demethyldolastatin (MMAD);MMAD (Demethyldolastatin 10;MMAD MonoMethyl Dolastatin 10
- CBNumber
- CB22666664
- Molecular Formula
- C41H66N6O6S
- Formula Weight
- 771.06
- MOL File
- 203849-91-6.mol
MonoMethyl Dolastatin 10 Property
- Boiling point:
- 906.1±65.0 °C(Predicted)
- Density
- 1.119±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 13.81±0.46(Predicted)
- color
- White to off-white
- InChIKey
- VXFWBBRRMOHFGR-UUFHNPECSA-N
- SMILES
- C(NC(=O)[C@H](C(C)C)NC)(=O)[C@H](C(C)C)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C1=NC=CS1)CC1=CC=CC=C1)=O)C
N-Bromosuccinimide Price
- Product number
- M425405
- Product name
- MonomethylAuristatinD(MMAD)
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 456565
- Product name
- Monomethyl Auristatin D
- Packaging
- 1mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- CS-1613
- Product name
- MMAD
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-1613
- Product name
- MMAD
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-1613
- Product name
- MMAD
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
MonoMethyl Dolastatin 10 Chemical Properties,Usage,Production
Description
Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor. Synonyms: Demethyldolastatin 10; Monomethylauristatin D; MMAD.
Uses
MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.
Biological Activity
mmad is a highly potent inhibitor of tubulin [1].mmad is one of the auristatins, which are used as the drugs of antibody drug conjugates (adcs). in adcs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of mabs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. as a payload of adcs, mmad is used to target the tubulin of the tumor cells. it can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1].additionally, mmad is reported to be used in the production of site-specific antibody drug conjugates (ndcs). in the ndcs, mmad is combined with anti-5t4 antibody or anti-her2 antibody. it is shown that the ndcs demonstrate better efficacy and pharmacokinetics [2].
in vivo
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].
target
tubulin
IC 50
Auristatin
References
[1] puja sapra, andrea t hooper, christopher j, o’donnell & hans-peter gerber. investigational antibody drug conjugates for solid tumors. expert opin. investig. drugs. 2011, 20(8):1131-1149.
[2] feng tiana, yingchun lu, anthony manibusan, aaron sellers et al. a general approach to site-specific antibody drug conjugates. pnas. 2014, february, 111(5): 1766-1771.
MonoMethyl Dolastatin 10 Preparation Products And Raw materials
Raw materials
Preparation Products
MonoMethyl Dolastatin 10 Suppliers
- Tel
- +81-8027837258; +8108027837258
- Fax
- 0081-80278372055
- sales@adachibio.com
- Country
- Japan
- ProdList
- 992
- Advantage
- 58
View Lastest Price from MonoMethyl Dolastatin 10 manufacturers
- Product
- MMAD;MonoMethyl Dolastatin 10 203849-91-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- MonoMethyl Dolastatin 10 203849-91-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13