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BM-1074

Product Name
BM-1074
CAS No.
1391108-10-3
Chemical Name
BM-1074
Synonyms
BM-1074;1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)-
CBNumber
CB22667388
Molecular Formula
C50H57ClN8O7S3
Formula Weight
1013.68
MOL File
1391108-10-3.mol
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BM-1074 Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO mg/mL Water mg/mL Ethanol mg/mL
pka
2.32±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B595855
Product name
BM-1074
Packaging
10mg
Price
$1680
Updated
2021/12/16
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BM-1074 Chemical Properties,Usage,Production

Uses

BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete, and durable tumor regression in vivo.

in vivo

BM-1074 (i.v., 15 mg/kg, daily, 5 days a week for 2 weeks) exhibits the maximum tolerated dose (MTD) (15 mg/kg) and strong antitumor activity in H146 tumor xenograft mice, as well as shows no significant weight loss (<5%) or other signs of toxicity[1].
BM-1074 (i.v., 15 mg/kg, single) induces strong apoptosis in H146 tumor tissues[1].

Animal Model:SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1]
Dosage:15 mg/kg
Administration:i.v., 15 mg/kg, daily, 5 days a week for 2 weeks
Result:Showed good toleration and did not cause significant weight loss or other signs of toxicity, also induced completely and persistent tumor regression in the H146 xenograft model.
Animal Model:SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1]
Dosage:15 mg/kg
Administration:i.v., 15 mg/kg, single dosage
Result:Induced robust cleavage of PARP and caspase-3 at both 3 and 6-hr time-points in H146 tumor tissues.

IC 50

Bcl-2: 1.8 nM (IC50); Bcl-xL: 6.9 nM (IC50)

BM-1074 Preparation Products And Raw materials

Raw materials

Preparation Products

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BM-1074 Suppliers

China 26 India 1 United States 2 Global 29
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ：2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4171
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7982
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58

1391108-10-3, BM-1074Related Search:


  • BM-1074
  • 1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)-
  • 1391108-10-3
  • C50H57ClN8O7S3