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BLASTICIDIN S

Product Name
BLASTICIDIN S
CAS No.
2079-00-7
Chemical Name
BLASTICIDIN S
Synonyms
blasticidin;bab;Blas;babs;Blaes;bcs-3;toabla-s;cytovirin;bcs-3、bla-s;blastizidin
CBNumber
CB2269508
Molecular Formula
C17H26N8O5
Formula Weight
422.45
MOL File
2079-00-7.mol
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BLASTICIDIN S Property

Melting point:
235°C
Boiling point:
539.06°C (rough estimate)
alpha 
D11 +108.4° (water)
Density 
1.1690 (rough estimate)
vapor pressure 
Low
refractive index 
1.6910 (estimate)
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble
form 
A solid
pka
2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases)
Water Solubility 
>30 g l-1(20 °C)
Stability:
Incompatible with strong oxidizing agents.
EPA Substance Registry System
Blasticidin S (2079-00-7)
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Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
24/25-36/37-45
RIDADR 
3172
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29349990
Hazardous Substances Data
2079-00-7(Hazardous Substances Data)
Toxicity
LD50 i.v. in mice: 2.82 mg/kg (Takeuchi)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0008653
Product name
BLASTICIDIN S
Purity
95.00%
Packaging
50MG
Price
$759.41
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008653
Product name
BLASTICIDIN S
Purity
95.00%
Packaging
100MG
Price
$839.45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008653
Product name
BLASTICIDIN S
Purity
95.00%
Packaging
250MG
Price
$1086.86
Updated
2021/12/16
AHH
Product number
MT-48228
Product name
BlasticidinS
Purity
98%
Packaging
0.5g
Price
$770
Updated
2021/12/16
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BLASTICIDIN S Chemical Properties,Usage,Production

Description

Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).

Uses

Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.

Uses

Blasticidin-S is used for the control of rice blast (PyricuZuria oryzae) by foliar application.

Definition

ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.

Production Methods

Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).

General Description

Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.

Pharmacology

Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.

Metabolic pathway

Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.

Metabolism

3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT50 < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).

Toxicity evaluation

Acute oral LD50 for male rats: 56.8, female rats: 55.9, male mice: 51.9, and female mice: 60.1 mg/kg. Acute percutaneous LD50 for rats >500 mg/kg. Eye: severe irritation.

Degradation

Blasticidin-S is obtained as white needle crystals which are very soluble in water. The compound is stable in the pH range 5-7 but it is unstable under alkaline conditions. It is readily degraded by sunlight when on the surface of rice plants with the main degradation product being cytosine (2) (Yamaguchi et al., 1972) as shown in Scheme 1.

BLASTICIDIN S Preparation Products And Raw materials

Raw materials

VEGETABLEPROTEIN Diphenylmethane streptomyces avermifilis BBK8 AMIKACIN SULFATE CREAM

Preparation Products

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BLASTICIDIN S Suppliers

China 34 Germany 2 India 1 South Korea 1 United Kingdom 7 United States 8 Global 53
Beijing HuaMeiHuLiBiological Chemical
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86-(0)29-85992781 17792393971
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View Lastest Price from BLASTICIDIN S manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Blasticidin S 2079-00-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-25
Career Henan Chemical Co
Product
BLASTICIDIN S 2079-00-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10t
Release date
2019-12-20

2079-00-7, BLASTICIDIN SRelated Search:

Chlorothalonil DITHIANON DODECYLBENZENE DODECYLBENZENE Sulfamic acid Dodecylbenzene BLASTICIDIN S H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HCL,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,BLASTICIDIN S HYDROCHLORIDE Blasticidin H blasticidin A blasticidin S deaminase BLASTICIDIN S HCL UN2811- blasticidin S-acetyltransferase Blasticidin S, HCl, Streptomyces griseochromogenes Blasticidin S sodium salt BLASTICIDIN S HCL,BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,Blasticidin S benzylaminobenzenesulfonate Blasticidin

  • 1(1’-Cytosinyl)-4-[L-3’-amino-5’(1’’-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronicacid
  • bab
  • Blas
  • Blaes
  • .beta.-D-erythro-Hex-2-enopyranuronic acid, 4-3-amino-5-(aminoiminomethyl)methylamino-1-oxopentylamino-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, (S)-
  • 1(1'-Cytosinyl)-4-[L-3'-amino-5'(1''-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronic acid
  • bcs-3、bla-s
  • Alkylate, "hard"
  • Alkylbenzene (branched)
  • Branched alkylbenzene
  • Branched detergent alkylate
  • Branched dodecylbenzene
  • Detergent alkylate (branched)
  • Dodecylbenzene (branched)
  • (2S)-3β-[[(3S)-3-Amino-5-(1-methylguanidino)pentanoyl]amino]-6α-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,6-dihydro-2H-pyran-2α-carboxylic acid
  • 4-[[(3S)-3-Amino-5-[[amino(imino)methyl]methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-2-hexenopyranuronic acid
  • 4-[[(S)-3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-2-hexenopyranuronic acid
  • Blastizidin s
  • Blasticidin S Hydrochloride in buffer solutionLiquid
  • Blasticidin S Hydrochloride (solid)
  • 3-(3-amino-5-(1-methylguanidino)-1-oxopentylamino-6-(4-amino-2-oxo-2,3-dihydro-pyrimidin-1-yl)-2,3-dihydro-(6H)-pyran-2-carboxylic acid blasticidin-s
  • S-[4-[3-amino-5-[(aminoiminomethyl) methylamino]-1-oxopentyl] amino]-1-[4-amino-2-oxo-1 (2H)-pyrimidinyl]-1,2,3,4-tetradeoxy-β-D-erythrohex-2-enopyranuronic acid
  • Cytovarin, Bla-S, 21544, A83094C, NSC 91770
  • babs
  • bcs-3
  • blasticidin
  • blastizidin
  • cytovirin
  • toabla-s
  • Vlasticidins
  • β-D-erythro-Hex-2-enopyranuronic acid, 4-[[(3S)-3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-
  • BLASTICIDIN S USP/EP/BP
  • BLASTICIDIN S
  • Blasticidin-S in Water
  • 2079-00-7
  • C17H26N8O5ClH
  • C17H26N8O5
  • FUNGICIDE