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BLASTICIDIN S HYDROCHLORIDE

Product Name
BLASTICIDIN S HYDROCHLORIDE
CAS No.
3513-03-9
Chemical Name
BLASTICIDIN S HYDROCHLORIDE
Synonyms
BLASTICIDIN S HCL;Blasticidine S HCl;BLASTICIDIN S 50MG;Blasticidin S (10 mg/ml);BLASTICIDIN S HYDROCHLORIDE;BLASTICIDINE S HYDROCHLORIDE;Blasticidin S (10 mg/mL in Solution);Blasticidine S hydrochloride solution;BLASTICIDIN S HYDROCHLORIDE USP/EP/BP;Blasticidin S hydrochloride≥ 98% (HPLC)
CBNumber
CB8383972
Molecular Formula
C17H27ClN8O5
Formula Weight
458.9
MOL File
3513-03-9.mol
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BLASTICIDIN S HYDROCHLORIDE Property

Melting point:
224-225 °C (decomp)
storage temp. 
−20°C
solubility 
Soluble in Water (greater than 25 mg/ml)
form 
Liquid
color 
White
Water Solubility 
Soluble in water. Insoluble in organic solvents.
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
28-36/37-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
1-10
HazardClass 
6.1
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
203350
Product name
Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem
Packaging
25mg
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
203351-M
Product name
Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity
sterile; sterile-filtered, suitable for cell culture
Packaging
10ml
Price
$583
Updated
2022/05/15
Sigma-Aldrich
Product number
203351-M
Product name
Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity
sterile; sterile-filtered, suitable for cell culture
Packaging
203351-10ML
Price
$583
Updated
2022/05/15
Sigma-Aldrich
Product number
15205
Product name
Blasticidine S hydrochloride
Packaging
25MG
Price
$173
Updated
2022/05/15
Sigma-Aldrich
Product number
15205
Product name
Blasticidine S hydrochloride
Packaging
100MG
Price
$476
Updated
2022/05/15
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BLASTICIDIN S HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4

Chemical Properties

White powder

Uses

Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.

Uses

Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.

Uses

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

General Description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.

storage

Store at -20°C

References

1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980

BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BLASTICIDIN S HYDROCHLORIDE Suppliers

Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18117592386
Email
3007522982@qq.com
Country
China
ProdList
52712
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58
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4648
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4515
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58

3513-03-9, BLASTICIDIN S HYDROCHLORIDERelated Search:


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  • C17H26N8O5HCl
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