BLASTICIDIN S HYDROCHLORIDE
- Product Name
- BLASTICIDIN S HYDROCHLORIDE
- CAS No.
- 3513-03-9
- Chemical Name
- BLASTICIDIN S HYDROCHLORIDE
- Synonyms
- BLASTICIDIN S HCL;Blasticidine S HCl;BLASTICIDIN S 50MG;Miewen S hydrochloride;Blasticidin S (10 mg/ml);BLASTICIDIN S HYDROCHLORIDE;BLASTICIDINE S HYDROCHLORIDE;Blasticidin S (10 mg/mL in Solution);Blasticidine S hydrochloride solution;BLASTICIDIN S HYDROCHLORIDE USP/EP/BP
- CBNumber
- CB8383972
- Molecular Formula
- C17H27ClN8O5
- Formula Weight
- 458.9
- MOL File
- 3513-03-9.mol
BLASTICIDIN S HYDROCHLORIDE Property
- Melting point:
- 224-225 °C (decomp)
- storage temp.
- −20°C
- solubility
- Soluble in Water (greater than 25 mg/ml)
- form
- Liquid
- color
- White
- Water Solubility
- Soluble in water. Insoluble in organic solvents.
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Safety
- Hazard Codes
- T+
- Risk Statements
- 28
- Safety Statements
- 28-36/37-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- F
- 1-10
- HazardClass
- 6.1
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 203350
- Product name
- Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem
- Packaging
- 25mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 203351-M
- Product name
- Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
- Purity
- sterile; sterile-filtered, suitable for cell culture
- Packaging
- 10ml
- Price
- $583
- Updated
- 2022/05/15
- Product number
- 203351-M
- Product name
- Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
- Purity
- sterile; sterile-filtered, suitable for cell culture
- Packaging
- 203351-10ML
- Price
- $583
- Updated
- 2022/05/15
- Product number
- 15205
- Product name
- Blasticidine S hydrochloride
- Packaging
- 25MG
- Price
- $173
- Updated
- 2022/05/15
- Product number
- 15205
- Product name
- Blasticidine S hydrochloride
- Packaging
- 100MG
- Price
- $476
- Updated
- 2022/05/15
BLASTICIDIN S HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
Chemical Properties
White powder
Uses
Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.
Uses
Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.
Uses
Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.
General Description
Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.
storage
Store at -20°C
References
1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980
BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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