BLASTICIDIN S HYDROCHLORIDE

ChemicalBook > CAS DataBase List > BLASTICIDIN S HYDROCHLORIDE

BLASTICIDIN S HYDROCHLORIDE

Product Name: BLASTICIDIN S HYDROCHLORIDE
CAS No.: 3513-03-9
Chemical Name: BLASTICIDIN S HYDROCHLORIDE
Synonyms: BLASTICIDIN S HCL;Blasticidine S HCl;BLASTICIDIN S 50MG;Miewen S hydrochloride;Blasticidin S (10 mg/ml);BLASTICIDIN S HYDROCHLORIDE;BLASTICIDINE S HYDROCHLORIDE;Blasticidin S (10 mg/mL in Solution);Blasticidine S hydrochloride solution;BLASTICIDIN S HYDROCHLORIDE USP/EP/BP
CBNumber: CB8383972
Molecular Formula: C17H27ClN8O5
Formula Weight: 458.9
MOL File: 3513-03-9.mol

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BLASTICIDIN S HYDROCHLORIDE Property

Melting point:: 224-225 °C (decomp)
storage temp.: −20°C
solubility: Soluble in Water (greater than 25 mg/ml)
form: Liquid
color: White
Water Solubility: Soluble in water. Insoluble in organic solvents.
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 28-36/37-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
F: 1-10
HazardClass: 6.1
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203350
Product name: Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem
Packaging: 25mg
Price: $216
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203351-M
Product name: Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity: sterile; sterile-filtered, suitable for cell culture
Packaging: 10ml
Price: $583
Updated: 2022/05/15

Sigma-Aldrich

Product number: 203351-M
Product name: Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity: sterile; sterile-filtered, suitable for cell culture
Packaging: 203351-10ML
Price: $583
Updated: 2022/05/15

Sigma-Aldrich

Product number: 15205
Product name: Blasticidine S hydrochloride
Packaging: 25MG
Price: $173
Updated: 2022/05/15

Sigma-Aldrich

Product number: 15205
Product name: Blasticidine S hydrochloride
Packaging: 100MG
Price: $476
Updated: 2022/05/15

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BLASTICIDIN S HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4

Chemical Properties

White powder

Uses

Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.

Uses

Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.

Uses

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

General Description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.

storage

Store at -20°C

References

1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980

BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BLASTICIDIN S HYDROCHLORIDE Suppliers

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3513-03-9, BLASTICIDIN S HYDROCHLORIDERelated Search:

Clindamycin hydrochloride Cefotaxime sodium MALFORMINC PHLEOMYCIN Geneticin Hygromycin B Ketanserin 5-Azacytidine WAY100635 CHIR-99021 Barasertib (AZD1152-HQPA) BLASTICIDIN S (S)-2-AMINO-BUT-3-EN-1-OL HYDROCHLORIDE L-ALLOISOTHREONINE HCL H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HYDROCHLORIDE BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES

BLASTICIDINE S HYDROCHLORIDE

BLASTICIDIN S HCL

BLASTICIDIN S HYDROCHLORIDE

BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES

Blasticidine S hydrochloride,Blasticidin S

(S)-4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-Hex-2-enopyranuronic acid,monohydrochloride

Blasticidine S HCl

Blasticidine S hydrochloride solution

Blasticidine S hydrochloride solution,1000ppm

Blasticidin S hydrochloride≥ 98% (HPLC)

Blasticidine S hydrochloride Solution, 100ppm

(2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride

Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem

(S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid hydrochloride

BLASTICIDIN S 50MG

BLASTICIDIN S HYDROCHLORIDE USP/EP/BP

Blasticidin S Hydrochloride for cell culture, 98%, Endotoxin (BET) 0.05EU/mg

Blasticidin S (10 mg/ml)

(2S,3S,6R)-6-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-((S)-3-amino-5-(1-methylguanidino)pentanamido)-3,6-dihydro-2H-pyran-2-carboxylic acid hydrochloride

Blasticidin S (10 mg/mL in Solution)

Miewen S hydrochloride

BlasticidineSHCl in Acetonitrile:Water=1:1

3513-03-9

C17H26N8O5HCl

C17H27ClN8O5

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