ChemicalBook > CAS DataBase List > 2',3'-O-Isopropylideneinosine

2',3'-O-Isopropylideneinosine

Product Name
2',3'-O-Isopropylideneinosine
CAS No.
2140-11-6
Chemical Name
2',3'-O-Isopropylideneinosine
Synonyms
2',3'-Ipr-Ino;-O-Isopropylideneinosine;2',3'-isopropylideneinosine;2',3'-ISOPROPYLIDENEINOSINE;2',3'-O-Isopropyrideneinosine;2',3'-0-lsopropylideneinosine;2‘,3'-O-lsopropylideneinosine;2',3'-O-Isopropylideneinosine;2',3'-O-Isopropylideneinosine;2'-O,3'-O-Isopropylideneinosine
CBNumber
CB2271080
Molecular Formula
C13H16N4O5
Formula Weight
308.29
MOL File
2140-11-6.mol
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2',3'-O-Isopropylideneinosine Property

Melting point:
263-272°C
Boiling point:
606.6±65.0 °C(Predicted)
Density 
1.80±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
14.14±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C13H16N4O5/c1-13(2)21-8-6(3-18)20-12(9(8)22-13)17-5-16-7-10(17)14-4-15-11(7)19/h4-6,8-9,12,18H,3H2,1-2H3,(H,14,15,19)/t6-,8-,9-,12-/m1/s1
InChIKey
LIEKLUBCIPVWQD-WOUKDFQISA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@@H]2OC(O[C@H]12)(C)C
CAS DataBase Reference
2140-11-6(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S450715
Product name
2',3'-ISOPROPYLIDENEINOSINE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
S450715
Product name
2'',3''-ISOPROPYLIDENEINOSINE
Purity
AldrichCPR
Packaging
250MG
Price
$29.8
Updated
2024/03/01
TCI Chemical
Product number
I0704
Product name
2',3'-O-Isopropylideneinosine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$25
Updated
2025/07/31
TRC
Product number
I868500
Product name
2'',3''-O-Isopropylideneinosine
Packaging
50g
Price
$115
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0000565
Product name
2',3'-O-ISOPROPYLIDENEINOSINE
Purity
95.00%
Packaging
1G
Price
$117.6
Updated
2021/12/16
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2',3'-O-Isopropylideneinosine Chemical Properties,Usage,Production

Chemical Properties

2',3'-O-Isopropylideneinosine is White Solid

Uses

2',3'-O-Isopropylideneinosine is an inosine derivative as antiviral, bactericidal, and antitumor agent for immunopotentiating uses.

Uses

A useful precursor for the preparation of nucleic acids

Synthesis

58-63-9

77-76-9

2140-11-6

To a solution of inosine (0.998 g, 3.72 mmol) in dimethylformamide (DMF, 30 mL) was sequentially added 2,2-dimethoxypropane (1.8 mL, 14.59 mmol) and p-toluenesulfonic acid monohydrate (0.038 g, 0.372 mmol). The reaction mixture was stirred under argon (Ar) protection for 24 hours. Upon completion of the reaction, DMF was removed by evaporation under reduced pressure, followed by alkalinization of the reaction mixture with 3% ammonia solution and evaporation again to dryness. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 95/5, v/v) to afford the target compound 22 in white foamy form in 80% yield. The product was characterized by 1H-NMR (200 MHz, DMSO-d6): δ 1.34, 1.50 (6H, s, (CH3)2C), 3.6 (2H, t, CH2-5'), 4.37 (1H, m, H-4'), 4.94 (1H, m, H-3'), 5.18 (1H, t, OH-5'), 5.37 (1H, dd. J = 3.7 Hz, H-2'), 6.12 (1H, d, J = 2.4 Hz, H-1'), 8.05 (1H, s, H-2), 8.32 (1H, s, H-8), and 12.44 (1H, br s, NH-3).ESI-MS analysis showed: m/z 309.1 [M + H]+, molecular formula C13H16N4O5, molecular weight 308.29.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 202 - 209
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 5, p. 2087 - 2103
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5349 - 5370
[4] Heterocycles, 2013, vol. 87, # 11, p. 2369 - 2384
[5] Chinese Chemical Letters, 2011, vol. 22, # 12, p. 1439 - 1442

2',3'-O-Isopropylideneinosine Preparation Products And Raw materials

Raw materials

Preparation Products

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2',3'-O-Isopropylideneinosine Suppliers

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View Lastest Price from 2',3'-O-Isopropylideneinosine manufacturers

Honest Joy Holdings Limited
Product
2',3'-O-Isopropylideneinosine
Price
US $0.00/KG
Min. Order
1KG
Purity
97.3%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
2',3'-O-Isopropylideneinosine 2140-11-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-15

2140-11-6, 2',3'-O-IsopropylideneinosineRelated Search:

Mesityl oxide Disodium 5'-Inosinate Isoprinosine Dideoxyinosine 6-Hydroxypurine 3-Isopropoxypropylamine 2'-Deoxyinosine 1-METHYL-1H-IMIDAZOLE-4-CARBALDEHYDE (1-Methyl-1H-imidazol-4-yl)methylamine (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol AICAR 2',3'-O-Isopropylideneguanosine Inosine 1,3-Dioxolane-4-methanol 2,2-Dimethyl-1,3-dioxolane-4-methanol [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanamine 2',3'-O-ISOPROPYLIDENE-5'-TRITYLINOSINE 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE

  • 2',3'-isopropylideneinosine
  • 2',3'-O-Isopropylidene-D-inosine
  • 2'',3''-O-ISOPROPYLIDENEINOSINE,98.0+%(LC)
  • 2',3'-O-(1-Methylethylidene)- Inosine
  • 9-(2,3-O-Isopropylidene-beta-D-ribofuranosyl)hypoxanthine
  • 2'-O,3'-O-Isopropylidene-2-deaminoguanosine
  • 2'-O,3'-O-Isopropylidene-6-hydroxy-6-deaminoadenosine
  • 2'-O,3'-O-Isopropylideneinosine
  • 2',3'-O-Isopropylideneinosine≥ 98% (HPLC)
  • 9-((3aR,4R,6R,6aR)-6-(HydroxyMethyl)-2,2-diMethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ol
  • -O-Isopropylideneinosine
  • 2',3'-O-Isopropylideneinosine&gt
  • Inosine, 2',3'-O-(1-methylethylidene)-
  • 2',3'-Ipr-Ino
  • 2',3'-O-Isopropylideneinosine USP/EP/BP
  • 2',3'-O-Isopropyrideneinosine
  • 2',3'-0-lsopropylideneinosine
  • 2‘,3'-O-lsopropylideneinosine
  • 2',3'-O-Isopropylideneinosine
  • 2',3'-ISOPROPYLIDENEINOSINE
  • 2′,3′-O-Isopropylideneinosine, CAS 2140-11-6
  • 2',3'-O-Isopropylideneinosine
  • 2140-11-6
  • 2140-11-06
  • 40-11-6
  • Heterocycles
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Bases & Related Reagents
  • Nucleotides