6-Hydroxypurine
- Product Name
- 6-Hydroxypurine
- CAS No.
- 68-94-0
- Chemical Name
- 6-Hydroxypurine
- Synonyms
- HYPOXANTHINE;9H-PURIN-6-OL;Hypoxanthine-d4;Hypoxanthine,99%;Hypoxanthine, 99.5%;3,7-dihydropurin-6-one;Azathioprine EP Impurity F;1,7-DIHYDRO-6H-PURIN-6-ONE;6H-Purin-6-one, 1,7-dihydro-;6H-Purin-6-one, 1,9-dihydro-
- CBNumber
- CB5378579
- Molecular Formula
- C5H4N4O
- Formula Weight
- 136.11
- MOL File
- 68-94-0.mol
6-Hydroxypurine Property
- Melting point:
- >300 °C (lit.)
- Boiling point:
- 250.36°C (rough estimate)
- Density
- 1.4295 (rough estimate)
- refractive index
- 1.8500 (estimate)
- storage temp.
- 2-8°C
- solubility
- 1 M NaOH: 25 mg/mL
- form
- powder
- pka
- 8.7(at 25℃)
- color
- Colorless to yellow to brown, darken on storage with no loss of purity
- Odor
- Odorless
- Water Solubility
- practically insoluble
- Merck
- 14,4869
- BRN
- 5811
- InChIKey
- FDGQSTZJBFJUBT-UHFFFAOYSA-N
- LogP
- -0.910 (est)
- CAS DataBase Reference
- 68-94-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Hypoxanthine(68-94-0)
- EPA Substance Registry System
- Hypoxanthine (68-94-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22-40
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- RTECS
- UP0791000
- Hazard Note
- Harmful
- TSCA
- Yes
- HS Code
- 29335990
- Toxicity
- LD50 intraperitoneal in mouse: 750mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- Y0002147
- Product name
- Mercaptopurine impurity A
- Purity
- CRS, European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0002147
- Price
- $156
- Updated
- 2024/03/01
- Product number
- 4010CBC
- Product name
- Hypoxanthine - CAS 68-94-0 - Calbiochem
- Purity
- Xanthine oxidase substrate.
- Packaging
- 25g
- Price
- $97.6
- Updated
- 2024/03/01
- Product number
- 1191226
- Product name
- Didanosine Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1490
- Updated
- 2024/03/01
- Product number
- H0311
- Product name
- Hypoxanthine
- Purity
- >98.0%(HPLC)(E)
- Packaging
- 5g
- Price
- $25
- Updated
- 2024/03/01
- Product number
- H0311
- Product name
- Hypoxanthine
- Purity
- >98.0%(HPLC)(E)
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
6-Hydroxypurine Chemical Properties,Usage,Production
Description
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Chemical Properties
White to off-white powder
Uses
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
Uses
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Uses
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.
Definition
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
General Description
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Biochem/physiol Actions
Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox
Purification Methods
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]
6-Hydroxypurine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Hydroxypurine Suppliers
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View Lastest Price from 6-Hydroxypurine manufacturers
- Product
- Hypoxanthine 68-94-0
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-05-22
- Product
- Hypoxanthine 68-94-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-10-31
- Product
- 6-Hydroxypurine 68-94-0
- Price
- US $999.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21