ChemicalBook > CAS DataBase List > 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

Product Name: 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
CAS No.: 5262-10-2
Chemical Name: 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
Synonyms: (2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid;CYCLO(-ASP-PHE);Cyclo(Phe-Asp-);CYCLO(L-ASP-L-PHE);Aspartame impurity A CRS;AspartaMe Related CoMpound A;cyclo(aspartyl-phenylalanyl);Cyclo(-Asp-Phe) (G-1695.0250);Cyclo(-Asp-Phe) (G-1695.1000);Aspartame USP Related Compound A
CBNumber: CB2271464
Molecular Formula: C13H14N2O4
Formula Weight: 262.26
MOL File: 5262-10-2.mol

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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Property

Melting point:: 270-272 °C(lit.)
Boiling point:: 667.4±40.0 °C(Predicted)
Density: 1.298±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Acetic Acid (Slightly, Heated, Sonicated), DMSO (Slightly)
form: powder
pka: 4.02±0.10(Predicted)
color: White to Off-White
optical activity: [α]20/D 9.0°, c = 0.9 in acetic acid
InChI: InChI=1S/C13H14N2O4/c16-11(17)7-10-13(19)14-9(12(18)15-10)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7H2,(H,14,19)(H,15,18)(H,16,17)/t9-,10-/m0/s1
InChIKey: VNHJXYUDIBQDDX-UWVGGRQHSA-N
SMILES: N1C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]1CC(O)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933599550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2420
Product name: Aspartame Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $494.95
Updated: 2025/07/31

Sigma-Aldrich

Product number: A1321000
Product name: Aspartame impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $164
Updated: 2025/07/31

Sigma-Aldrich

Product number: 421650
Product name: (2S-cis)-(?)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid
Purity: 97%
Packaging: 1g
Price: $937
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1043728
Product name: Aspartame Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1380
Updated: 2024/03/01

Sigma-Aldrich

Product number: 89274
Product name: (2S-cis)-(?)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid
Purity: analytical standard
Packaging: 50mg
Price: $210
Updated: 2025/07/31

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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid (Aspartame EP Impurity A) is the diketopiperazine impurity of the sweetening agent Aspartame (A790015). It is also found in in processed cocoa powder.

General Description

(2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid is a piperazine scaffold that can be used to construct biologically active compounds with therapeutic applications.

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid 97% 5262-10-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

5262-10-2, 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACIDRelated Search:

2-Benzylpiperazine CIS-2,5-DIMETHYLPIPERAZINE 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID CYCLO(-ALA-ALA) DL-2-AMINOPROPIONIC ANHYDRIDE (S)-3-(2-HYDROXYETHYL)-2,5-DIKETOPIPERAZINE CYCLO(-ALA-GLY) Piperazine, 2-(phenylmethyl)-, (2S)- (9CI) Piperazinone, 3-(phenylmethyl)-, (S)- (9CI) CYCLO(-ASP-GLY) H-PHE-BETA-ALA-OH CYCLO(-GLY-PHE) [[p-(2-methoxyethyl)phenoxy]methyl]oxirane H-ASP-PHE-OH Aspartame DL-Phenylalanine 5-Benzyl-3,6-dioxo-2-piperazineacetic acid sodium salt

Aspartame Impurity 1（Aspartame EP Impurity A）

2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]acetic acid

2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]ethanoic acid

2-[(2S,5S)-5-(benzyl)-3,6-diketo-piperazin-2-yl]acetic acid

AspartaMe Related CoMpound A

(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid

Aspartame Related Compound A (25 mg) (5-Benzyl-3,6-dioxo-2-piperazineacetic Acid)

(2S,5S)-3,6-Dioxo-5-(phenylMethyl)-2-piperazineacetic Acid

(2S-cis)-3,6-Dioxo-5-(phenylMethyl)-2-piperazineacetic Acid

AspartaMe-Related CoMpound A, (2S,5S)-5-Benzyl-3,6-dioxo2-piperazineacetic acid

2-((2S,5S)-5-benzyl-3,6-dioxopiperazin-2-yl)acetic acid

(2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid 97%

2-(5-Benzyl-3,6-dioxopiperazin-2-yl)

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

(2S-CIS)-(-)-5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

CYCLO(-ASP-PHE)

CYCLO(L-ASP-L-PHE)

(2S-cis)-(-)-5-benzyl-3,6-dioxo-2-piperazineaceti

cyclo(aspartyl-phenylalanyl)

(2S)-3,6-Dioxo-5β-(phenylmethyl)-2β-piperazineacetic acid

(2S)-3,6-Dioxo-5β-benzylpiperazine-2β-acetic acid

5β-Benzyl-3,6-dioxopiperazine-2β-acetic acid

Cyclo(Phe-Asp-)

Cefadroxil Impurity 3（Aspartame Degradation Product，Aspartame Impurity A）

Aspartame impurity A CRS

Aspartame USP Related Compound A

2-Piperazineacetic acid, 3,6-dioxo-5-(phenylmethyl)-, (2S,5S)-

Aspartame EP Impurity A/ Aspartame Related Compound A

Cyclo(-Asp-Phe) (G-1695.0250)

Cyclo(-Asp-Phe) (G-1695.1000)

Aspartame EP Impurity AQ: What is Aspartame EP Impurity A Q: What is the CAS Number of Aspartame EP Impurity A Q: What is the storage condition of Aspartame EP Impurity A Q: What are the applications of Aspartame EP Impurity A

Aspartame Related Compound A (5-Benzyl-3,6-dioxo-2-piperazineacetic Acid) (1043728)

(2<i>S</i>-<i>cis</i>)-(?)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid

5262-10-2

5262-10-2 CAT号:B31006

526-10-2

Heterocyclic Building Blocks

Piperazines

Chiral Building Blocks

Asymmetric Synthesis

Aromatics

Heterocycles

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Piperazines