ChemicalBook > CAS DataBase List > 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID

Product Name
5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
CAS No.
5262-10-2
Chemical Name
5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
Synonyms
(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid;CYCLO(-ASP-PHE);Cyclo(Phe-Asp-);CYCLO(L-ASP-L-PHE);Aspartame impurity A CRS;AspartaMe Related CoMpound A;cyclo(aspartyl-phenylalanyl);Cyclo(-Asp-Phe) (G-1695.0250);Cyclo(-Asp-Phe) (G-1695.1000);Aspartame USP Related Compound A
CBNumber
CB2271464
Molecular Formula
C13H14N2O4
Formula Weight
262.26
MOL File
5262-10-2.mol
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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Property

Melting point:
270-272 °C(lit.)
Boiling point:
667.4±40.0 °C(Predicted)
Density 
1.298±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Acetic Acid (Slightly, Heated, Sonicated), DMSO (Slightly)
pka
4.02±0.10(Predicted)
color 
White to Off-White
optical activity
[α]20/D 9.0°, c = 0.9 in acetic acid
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933599550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2420
Product name
Aspartame Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
421650
Product name
(2S-cis)-(?)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid
Purity
97%
Packaging
1g
Price
$545.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1043728
Product name
Aspartame Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1380
Updated
2024/03/01
Sigma-Aldrich
Product number
A1321000
Product name
Aspartame impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
a1321000
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
89274
Product name
(2S-cis)-(?)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid
Purity
analytical standard
Packaging
50mg
Price
$204
Updated
2024/03/01
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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid (Aspartame EP Impurity A) is the diketopiperazine impurity of the sweetening agent Aspartame (A790015). It is also found in in processed cocoa powder.

General Description

(2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid is a piperazine scaffold that can be used to construct biologically active compounds with therapeutic applications.

5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID Suppliers

Canada 1 China 91 India 6 Japan 1 Switzerland 2 United Kingdom 2 United States 10 Global 113
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Senn Chemicals AG
Tel
--
Fax
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Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid 97% 5262-10-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

5262-10-2, 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACIDRelated Search:

2-Benzylpiperazine CIS-2,5-DIMETHYLPIPERAZINE 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID CYCLO(-ALA-ALA) DL-2-AMINOPROPIONIC ANHYDRIDE (S)-3-(2-HYDROXYETHYL)-2,5-DIKETOPIPERAZINE CYCLO(-ALA-GLY) Piperazine, 2-(phenylmethyl)-, (2S)- (9CI) Piperazinone, 3-(phenylmethyl)-, (S)- (9CI) CYCLO(-ASP-GLY) H-PHE-BETA-ALA-OH CYCLO(-GLY-PHE) [[p-(2-methoxyethyl)phenoxy]methyl]oxirane H-ASP-PHE-OH Aspartame DL-Phenylalanine 5-Benzyl-3,6-dioxo-2-piperazineacetic acid sodium salt

  • Aspartame Impurity 1（Aspartame EP Impurity A）
  • 2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]acetic acid
  • 2-[(2S,5S)-3,6-dioxo-5-(phenylmethyl)piperazin-2-yl]ethanoic acid
  • 2-[(2S,5S)-5-(benzyl)-3,6-diketo-piperazin-2-yl]acetic acid
  • AspartaMe Related CoMpound A
  • (2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineacetic Acid
  • Aspartame Related Compound A (25 mg) (5-Benzyl-3,6-dioxo-2-piperazineacetic Acid)
  • (2S,5S)-3,6-Dioxo-5-(phenylMethyl)-2-piperazineacetic Acid
  • (2S-cis)-3,6-Dioxo-5-(phenylMethyl)-2-piperazineacetic Acid
  • AspartaMe-Related CoMpound A, (2S,5S)-5-Benzyl-3,6-dioxo2-piperazineacetic acid
  • 2-((2S,5S)-5-benzyl-3,6-dioxopiperazin-2-yl)acetic acid
  • (2S-cis)-(-)-5-Benzyl-3,6-dioxo-2-piperazineacetic acid 97%
  • 2-(5-Benzyl-3,6-dioxopiperazin-2-yl)
  • 5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
  • (2S-CIS)-(-)-5-BENZYL-3,6-DIOXO-2-PIPERAZINEACETIC ACID
  • CYCLO(-ASP-PHE)
  • CYCLO(L-ASP-L-PHE)
  • (2S-cis)-(-)-5-benzyl-3,6-dioxo-2-piperazineaceti
  • cyclo(aspartyl-phenylalanyl)
  • (2S)-3,6-Dioxo-5β-(phenylmethyl)-2β-piperazineacetic acid
  • (2S)-3,6-Dioxo-5β-benzylpiperazine-2β-acetic acid
  • 5β-Benzyl-3,6-dioxopiperazine-2β-acetic acid
  • Cyclo(Phe-Asp-)
  • Cefadroxil Impurity 3（Aspartame Degradation Product，Aspartame Impurity A）
  • Aspartame impurity A CRS
  • Aspartame USP Related Compound A
  • 2-Piperazineacetic acid, 3,6-dioxo-5-(phenylmethyl)-, (2S,5S)-
  • Aspartame EP Impurity A/ Aspartame Related Compound A
  • Cyclo(-Asp-Phe) (G-1695.0250)
  • Cyclo(-Asp-Phe) (G-1695.1000)
  • Aspartame EP Impurity AQ: What is Aspartame EP Impurity A Q: What is the CAS Number of Aspartame EP Impurity A Q: What is the storage condition of Aspartame EP Impurity A Q: What are the applications of Aspartame EP Impurity A
  • Aspartame Related Compound A (5-Benzyl-3,6-dioxo-2-piperazineacetic Acid) (1043728)
  • 5262-10-2
  • 5262-10-2 CAT号:B31006
  • 526-10-2
  • Heterocyclic Building Blocks
  • Piperazines
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Aromatics
  • Heterocycles
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines