ChemicalBook > CAS DataBase List > 4SC-202 (free base)

4SC-202 (free base)

Product Name
4SC-202 (free base)
CAS No.
910462-43-0
Chemical Name
4SC-202 (free base)
Synonyms
CS-1285;Domatinostat;domatinostat HCl;4SC-202 (free base);Domatinostat (4SC202);Domatinostat, 10 mM in DMSO;HDAC,Domatinostat,Apoptosis,inhibit,Inhibitor,Histone deacetylases;(E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide;(2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide;2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-
CBNumber
CB22715601
Molecular Formula
C23H21N5O3S
Formula Weight
447.51
MOL File
910462-43-0.mol
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4SC-202 (free base) Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 58 mg/mL (129.61 mM)
form 
Solid
pka
12.60±0.70(Predicted)
color 
White to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3275
Product name
Domatinostat
Purity
99.08%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-3275
Product name
Domatinostat
Purity
99.08%
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-3275
Product name
Domatinostat
Purity
99.08%
Packaging
50mg
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-3275
Product name
Domatinostat
Purity
99.08%
Packaging
100mg
Price
$1020
Updated
2021/12/16
DC Chemicals
Product number
DC8423
Product name
4SC-202freebase
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
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4SC-202 (free base) Chemical Properties,Usage,Production

Uses

4SC-202 acts as a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes with an IC50 value.

in vivo

Oral gavage of Domatinostat (4SC-202 free base) inhibits HT-29 xenograft growth in nude mice, and when combined with oxaliplatin, its activity is further strengthened[2].

IC 50

HDAC-3: 0.57 μM (IC50); HDAC-2: 1.12 μM (IC50); HDAC-1: 1.2 μM (IC50); HDAC-11: 9.7 μM (IC50); HDAC-5: 11.3 μM (IC50); HDAC-10: 21 μM (IC50); HDAC-9: 50 μM (IC50)

4SC-202 (free base) Preparation Products And Raw materials

Raw materials

Preparation Products

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4SC-202 (free base) Suppliers

China 66 United States 8 USA 1 Global 75
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60

910462-43-0, 4SC-202 (free base)Related Search:

FORMANILIDE 4-Aminodiphenylamine

  • 4SC-202 (free base)
  • (E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide
  • (2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide
  • CS-1285
  • 2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-
  • Domatinostat
  • domatinostat HCl
  • Domatinostat (4SC202)
  • HDAC,Domatinostat,Apoptosis,inhibit,Inhibitor,Histone deacetylases
  • Domatinostat, 10 mM in DMSO
  • 910462-43-0
  • Inhibitors