ChemicalBook > CAS DataBase List > Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

Product Name: Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
CAS No.: 1034305-11-7
Chemical Name: Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
Synonyms: Ipragliflozin-005;pragliflozin Impurity;Ipragliflozin Impurity 11;Ipragliflozin Impurity 10;Ipragliflozin interMdiate;1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol;benzo[b]thiophen-2-yl(5-broMo-2-fluorophenyl)Methanol;α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol,;alpha-(5-Bromo-2-fluorophenyl)benzothiophene-2-methanol;Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
CBNumber: CB22716138
Molecular Formula: C15H10BrFOS
Formula Weight: 337.21
MOL File: 1034305-11-7.mol

Less

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Property

Boiling point:: 458.7±40.0 °C(Predicted)
Density: 1.597±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 12.52±0.20(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P331Do NOT induce vomiting.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: B411265
Product name: α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol,
Packaging: 50mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-M2883
Product name: Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
Packaging: 1g
Price: $137
Updated: 2021/12/16

ChemScene

Product number: CS-M2883
Product name: Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
Packaging: 250mg
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: 3662DP
Product name: Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
Packaging: 1g
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-M2883
Product name: Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
Packaging: 5g
Price: $512
Updated: 2021/12/16

Less

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Chemical Properties,Usage,Production

Synthesis

93777-26-5

95-15-8

1034305-11-7

At -78 °C, 16.6 g (124 mmol) of benzothiophene was dissolved in 200 mL of tetrahydrofuran. 78.5 mL (937 mmol) of n-butyllithium was slowly added, keeping the reaction temperature at -78 °C with continuous stirring for 1.5 hours. Subsequently, 23.95 g (118 mmol) of 5-bromo-2-fluorobenzaldehyde was dissolved in 300 mL of tetrahydrofuran and this solution was added drop-wise to the above benzothiophene solution and stirring was continued at -78 °C for 2 hours. Upon completion of the reaction, water and ether were added to the mixture for extraction. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 35.4 g, with 99.5% purity and 89% yield.

References

[1] Patent: CN108276396, 2018, A. Location in patent: Paragraph 0041; 0046; 0047; 0062; 0077
[2] Patent: EP2105442, 2009, A1. Location in patent: Page/Page column 13
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3263 - 3279

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Suppliers

China 42 India 1 United Kingdom 1 United States 2 Global 46

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604 13057662806
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 500
Advantage: 65

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.

Tel: 0531-58897130 15508676053
Email: drug_impurity@sdcclh.com
Country: China
ProdList: 2268
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9990
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Tel: 1701086315
Fax: 1701086315@qq.com
Email: dexuanpharma@126.com
Country: China
ProdList: 9475
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Mancinor Technology Co., Ltd.

Tel: 19719236623
Email: 2885515945@qq.com
Country: China
ProdList: 1544
Advantage: 58

Wuhan Yihe Technology Co., Ltd

Tel: 1842-7358862 18427358864
Email: yihekeji@chembuying.com
Country: China
ProdList: 940
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Anhui Xunrui Chemical Co., Ltd

Tel: 19159025340
Email: sunrui@hfshly.com
Country: China
ProdList: 469
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Nanjing Lebang Pharmaceutical Technology Co., Ltd

Tel: 18860950986
Email: tangmanman@lebangpharma.com
Country: China
ProdList: 650
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9119
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd

Tel: 020-18102736 18102736234
Email: LK@zlstandards.com
Country: China
ProdList: 8206
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 029-81136151 17392212881
Email: 1095@dideu.com
Country: China
ProdList: 10001
Advantage: 58

Fuxin Long Rui Pharmaceutical

Tel: 1381-0598707 13683261597
Email: sales3@huikangchem.com
Country: China
ProdList: 209
Advantage: 58

Sichuan jiayinglai technology CO.,LTD

Tel: 028-64159575
Email: 1678230860@qq.com
Country: China
ProdList: 6511
Advantage: 58

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Tel: +86-13017695106 +86-13676922317
Email: jiuyitime@fdachem.com
Country: China
ProdList: 16513
Advantage: 58

Chongqing jooe co., ltd

Tel: +undefined86-15223382610
Email: info@jooe.com
Country: China
ProdList: 6208
Advantage: 58

Kindchem(Nanjing)Co.,Ltd

Tel: +86-025-025-85281586 +8618651653755
Fax: 025-68661290
Email: sales@kindchem.cn
Country: China
ProdList: 1226
Advantage: 58

Ruifuxin Jiangsu Pharmaceutical Co., Ltd.

Tel: --
Fax: --
Email: billior@rivocean.com
Country: China
ProdList: 63
Advantage: 58

Rivocean Group Co., Ltd.

Tel: --
Fax: --
Email: dinghaifen@rivocean.com
Country: China
ProdList: 118
Advantage: 50

Less

View Lastest Price from Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- manufacturers

Career Henan Chemical Co

Product: Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- 1034305-11-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

1034305-11-7, Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-Related Search:

7-CYANO-BENZO[B]THIOPHENE Enantiomer Efavirenz (S)-5-chloro-a-(Cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-a- (trifluoromethyl) benzenemethanol (E-4) [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester (S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL Efavirenz AMino Alcohol Ethyl CarbaMate Efavirenz Related Compound C (20 mg) (6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline) (1S,2R)-N-TOSYLEPHEDRINE EmedastineN-Oxide Efavirenz Related Compound B (15 mg) ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) 6-chloro-4-pent-1-ynyl-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one (R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE Pioglitazone hydrochloride Saxagliptin Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Ipragliflozin

Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

benzo[b]thiophen-2-yl(5-broMo-2-fluorophenyl)Methanol

Ipragliflozin interMdiate

1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol

alpha-(5-Bromo-2-fluorophenyl)benzothiophene-2-methanol

Ipragliflozin-005

α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol,

Ipragliflozin Impurity 10

Ipragliflozin Impurity 11

pragliflozin Impurity

alpha-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol

1034305-11-7

C15H10BrFOS