Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-

Application

Product Name: Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-
CAS No.: 1034305-23-1
Chemical Name: Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-
Synonyms: Ipragliflozin-003;Azilsartan Impurity 65;Ipragliflozin Impurity 7;Ipragliflozin Impurity A;Ipragliflozin impurity A (C7);Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-;Methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-α-D-glucopyranoside;Methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-α-D-glucopyranoside;Methyl 1-C-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-alpha-glucopyranoside;α-D-Glucopyranoside, methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-
CBNumber: CB22711597
Molecular Formula: C22H23FO6S
Formula Weight: 434.48
MOL File: 1034305-23-1.mol

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Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Property

storage temp.: 2-8°C(protect from light)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A125636
Product name: (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Purity: 95+%
Packaging: 100mg
Price: $27
Updated: 2021/12/16

Ambeed

Product number: A125636
Product name: (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Purity: 95+%
Packaging: 250mg
Price: $52
Updated: 2021/12/16

Ambeed

Product number: A125636
Product name: (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Purity: 95+%
Packaging: 1g
Price: $129
Updated: 2021/12/16

Crysdot

Product number: CD11362231
Product name: (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Purity: 95+%
Packaging: 1g
Price: $515
Updated: 2021/12/16

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Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Chemical Properties,Usage,Production

Application

Methyl 1-C-[3-(benzo[B]thiophene-2-ylmethyl)-4-fluorophenyl]-ALPHA-D-glucopyranoside can be used as an analytical standard and reference, mainly in laboratory research and development processes and chemical production processes.

Synthesis

67-56-1

1034305-17-3

32469-28-6

1034305-23-1

A tetrahydrofuran solution of 0.9 M n-butylmagnesium chloride (0.9 M, 7.3 mL) was slowly added to toluene (18.0 mL) at -16 °C. Subsequently, n-hexane solution of n-butyllithium (2.66 M, 4.9 mL) was added dropwise at -12 °C and stirred for 16 min in the range of -12 to -15 °C. 2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene (Compound I, 2.000 g) was dissolved in toluene (10.0 mL) and added dropwise to the reaction system at -12 to -15 °C, the dropwise process lasted for 1 hour. Next, a toluene solution (10.0 mL) of (3S,4S,5R,6R)-3,4,5-tris((trimethylmethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (Compound II, 3.197 g) was added dropwise to the reaction solution and stirred for 3 hours at -12 to -15 °C. Upon completion of the reaction, the mixture was poured into a methanol solution (10.0 mL) of methanesulfonic acid (3.0 mL) at 0 °C or lower, followed by stirring for 16 hours and 36 minutes at room temperature. The reaction mixture was quenched with an aqueous sodium carbonate solution of pH about 8. The organic layer was washed with saturated brine (10 mL, once), dried over anhydrous sodium sulfate, and extracted with ethyl acetate (50 mL, twice). After filtration, the solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography to afford the target product (2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophene-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5triol (2.336 g, 86.4% yield).

References

[1] Patent: TW2016/2128, 2016, A. Location in patent: Paragraph 0024; 0025
[2] Patent: EP2105442, 2009, A1. Location in patent: Page/Page column 14

Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Suppliers

China 48 India 2 United Kingdom 1 United States 1 Global 52

Anhui Lianchuang Biological Medicine Co.,Ltd

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Chongqing Carechem Co.,Ltd.

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View Lastest Price from Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- manufacturers

Shanghai Yingrui Biopharma Co., Ltd.

Product: (2S,3R,4S,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 1034305-23-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100t
Release date: 2018-03-06

1034305-23-1, Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-Related Search:

CPNQ Bromothymol Blue 2-Methylindole Trimethylamine Octadecyl methacrylate Vitamin B series (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol (2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Ipragliflozin

Ipragliflozin Impurity A

Ipragliflozin-003

Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-

Methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-alpha-D-glucopyranoside

(2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophen-2-ylMethyl)-4-fluorophenyl)-6-(hydroxyMethyl)-2-Methoxytetrahydro-2H-pyran-3,4,5-triol

Methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-α-D-glucopyranoside

Ipragliflozin impurity A (C7)

Methyl 1-C-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-alpha-glucopyranoside

α-D-Glucopyranoside, methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-

Azilsartan Impurity 65

Ipragliflozin Impurity 7

Methyl 1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-α-D-glucopyranoside

(2S,3R,4S,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol

1034305-23-1

C22H23FO6S