L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)

Product Name: L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)
CAS No.: 951382-34-6
Chemical Name: L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)
Synonyms: CPD1060;l-prolinecompd;Ipragliflozin-002-L;Azilsartan Impurity 62;lpragliflozin L-Proline;l-prolinecompd.with(1s)-1,5-anhydro-1-c-(3-(benzo(b)thien-2-...;L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol;L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1);L-Prolinecompd.with(1S)-1,5-anhydro-1-C-[3-(benzChemicalbooko[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol(1:1);L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)ChemicalBook
CBNumber: CB42717326
Molecular Formula: C21H21FO5S.C5H9NO2
Formula Weight: 519.58
MOL File: 951382-34-6.mol

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L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alichem

Product number: 951382346
Product name: IpragliflozinL-Proline
Packaging: 1g
Price: $202
Updated: 2021/12/16

Chemenu

Product number: CM133072
Product name: L-prolinecompoundwith(2S,3R,4R,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(1:1)
Purity: 95%
Packaging: 1g
Price: $204
Updated: 2021/12/16

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L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Chemical Properties,Usage,Production

Uses

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

in vivo

Ipragliflozin (L-Proline) shows good pharmacokinetic properties following oral dosing, and dose-dependently increases urinary glucose excretion, which lasts for over 12 h in normal mice ^[3]. Oral administration of ipragliflozin increases urinary glucose excretion in a dose-dependent manner, an effect which is significant at doses of 0.3 mg/kg or higher and lasts over 12 h^[4]. Single administration of ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance ^[5].

IC 50

SGLT2

References

[1] Imamura M, et al. Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Bioorg Med Chem. 2012 May 15;20(10):3263-79. DOI:10.1016/j.bmc.2012.03.051
[2] Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701. DOI:10.1124/jpet.112.191593
[3] Tahara A, et al. Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):423-36. DOI:10.1007/s00210-011-0713-z
[4] Tahara A, et al. Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice. J Pharmacol Sci. 2012;120(1):36-44. DOI:10.1254/jphs.12089fp
[5] Tahara A, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol. 2013 Sep 5;715(1-3):246-55. DOI:10.1016/j.ejphar.2013.05.014

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Suppliers

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View Lastest Price from L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Azilsartan Impurity 62 951382-34-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 50000KG/month
Release date: 2024-10-22

Career Henan Chemical Co

Product: L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) 951382-34-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

951382-34-6, L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)Related Search:

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Ipragliflozin

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)

Ipragliflozin-002-L

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1)ChemicalBook

CPD1060

l-prolinecompd

L-proline compound with (3R,4R,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (1:1)

(2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol,(2S)-pyrrolidine-2-carboxylic acid

Azilsartan Impurity 62

l-prolinecompd.with(1s)-1,5-anhydro-1-c-(3-(benzo(b)thien-2-...

Ipragliflozin L-prolineQ: What is Ipragliflozin L-proline Q: What is the CAS Number of Ipragliflozin L-proline Q: What is the storage condition of Ipragliflozin L-proline Q: What are the applications of Ipragliflozin L-proline

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol

(2S,3R,4R,5S,6R)-2-(3-(Benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (S)-Pyrrolidine-2-carboxylic acid

lpragliflozin L-Proline

L-Prolinecompd.with(1S)-1,5-anhydro-1-C-[3-(benzChemicalbooko[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol(1:1)

951382-34-6

C5H9NO2C21H21FO5S

C21H21FO5SC5H9NO2