Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
- Product Name
- Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
- CAS No.
- 1034305-11-7
- Chemical Name
- Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
- Synonyms
- Ipragliflozin-005;pragliflozin Impurity;Ipragliflozin Impurity 11;Ipragliflozin Impurity 10;Ipragliflozin interMdiate;1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol;benzo[b]thiophen-2-yl(5-broMo-2-fluorophenyl)Methanol;α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol,;alpha-(5-Bromo-2-fluorophenyl)benzothiophene-2-methanol;Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
- CBNumber
- CB22716138
- Molecular Formula
- C15H10BrFOS
- Formula Weight
- 337.21
- MOL File
- 1034305-11-7.mol
Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Property
- Boiling point:
- 458.7±40.0 °C(Predicted)
- Density
- 1.597±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 12.52±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H304May be fatal if swallowed and enters airways
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P331Do NOT induce vomiting.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B411265
- Product name
- α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol,
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-M2883
- Product name
- Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-M2883
- Product name
- Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- 3662DP
- Product name
- Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-M2883
- Product name
- Benzo[b]thiophene-2-methanol,α-(5-bromo-2-fluorophenyl)-
- Packaging
- 5g
- Price
- $512
- Updated
- 2021/12/16
Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Chemical Properties,Usage,Production
Synthesis
93777-26-5
95-15-8
1034305-11-7
At -78 °C, 16.6 g (124 mmol) of benzothiophene was dissolved in 200 mL of tetrahydrofuran. 78.5 mL (937 mmol) of n-butyllithium was slowly added, keeping the reaction temperature at -78 °C with continuous stirring for 1.5 hours. Subsequently, 23.95 g (118 mmol) of 5-bromo-2-fluorobenzaldehyde was dissolved in 300 mL of tetrahydrofuran and this solution was added drop-wise to the above benzothiophene solution and stirring was continued at -78 °C for 2 hours. Upon completion of the reaction, water and ether were added to the mixture for extraction. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 35.4 g, with 99.5% purity and 89% yield.
References
[1] Patent: CN108276396, 2018, A. Location in patent: Paragraph 0041; 0046; 0047; 0062; 0077
[2] Patent: EP2105442, 2009, A1. Location in patent: Page/Page column 13
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3263 - 3279
Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- manufacturers
- Product
- Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- 1034305-11-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09