ChemicalBook > CAS DataBase List > IM-12
IM-12
- Product Name
- IM-12
- CAS No.
- 1129669-05-1
- Chemical Name
- IM-12
- Synonyms
- IM-12;CS-2144;CS-1819;IM-12 USP/EP/BP;The GSK3β Inhibitor XIX;THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12;3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;Glycogen synthase kinase-3,Glycogen synthase kinase 3,IM12,Inhibitor,inhibit,IM-12,GSK-3;3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- CBNumber
- CB22716259
- Molecular Formula
- C22H20FN3O2
- Formula Weight
- 377.41
- MOL File
- 1129669-05-1.mol
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IM-12 Property
- Melting point:
- 187 °C
- Boiling point:
- 600.2±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥9mg/mL
- form
- powder
- pka
- 16.77±0.30(Predicted)
- color
- yellow-orange
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0084
- Product name
- IM-12
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $136
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0084
- Product name
- IM-12
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $478
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 17673
- Product name
- IM-12
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17673
- Product name
- IM-12
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17673
- Product name
- IM-12
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
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IM-12 Chemical Properties,Usage,Production
Description
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.
Uses
3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3β).
Definition
ChEBI: 3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione is an organonitrogen compound, an organooxygen compound and a member of maleimides. It is functionally related to an alpha-amino acid.
References
[1]. schmöle ac, brennführer a, karapetyan g, et al. novel indolylmaleimide acts as gsk-3beta inhibitor in human neural progenitor cells. bioorg med chem, 2010, 18(18): 6785-6795.
IM-12 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IM-12 manufacturers
Career Henan Chemical Co
- Product
- IM-12 1129669-05-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23