GSK-3BETA INHIBITOR XII
- Product Name
- GSK-3BETA INHIBITOR XII
- CAS No.
- 601514-19-6
- Chemical Name
- GSK-3BETA INHIBITOR XII
- Synonyms
- TWS11;TWS S;CS-445;TWS119;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;GSK-3BETA INHIBITOR XII;GSK-3β Inhibitor, TWS119
- CBNumber
- CB2803764
- Molecular Formula
- C18H14N4O2
- Formula Weight
- 318.33
- MOL File
- 601514-19-6.mol
GSK-3BETA INHIBITOR XII Property
- Melting point:
- 249 °C
- Density
- 1.42
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
- pka
- 8.99±0.10(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 361554
- Product name
- GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
- Packaging
- 1mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 361554
- Product name
- GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
- Packaging
- 5mg
- Price
- $532
- Updated
- 2024/03/01
- Product number
- SML1271
- Product name
- TWS119
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $115
- Updated
- 2023/06/20
- Product number
- SML1271
- Product name
- TWS119
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $451
- Updated
- 2023/06/20
- Product number
- 10011251
- Product name
- TWS119
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
GSK-3BETA INHIBITOR XII Chemical Properties,Usage,Production
Uses
TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
Uses
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
Definition
ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.
General Description
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biological Activity
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Biochem/physiol Actions
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
target
GSK-3β
storage
Store at +4°C
References
[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.
GSK-3BETA INHIBITOR XII Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GSK-3BETA INHIBITOR XII manufacturers
- Product
- GSK-3BETA INHIBITOR XII 601514-19-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23