ChemicalBook > CAS DataBase List > GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII

Product Name
GSK-3BETA INHIBITOR XII
CAS No.
601514-19-6
Chemical Name
GSK-3BETA INHIBITOR XII
Synonyms
TWS11;TWS S;CS-445;TWS119;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;GSK-3BETA INHIBITOR XII;GSK-3β Inhibitor, TWS119
CBNumber
CB2803764
Molecular Formula
C18H14N4O2
Formula Weight
318.33
MOL File
601514-19-6.mol
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GSK-3BETA INHIBITOR XII Property

Melting point:
249 °C
Density 
1.42
storage temp. 
2-8°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
pka
8.99±0.10(Predicted)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
361554
Product name
GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
Packaging
1mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
361554
Product name
GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
Packaging
5mg
Price
$532
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1271
Product name
TWS119
Purity
≥98% (HPLC)
Packaging
5MG
Price
$115
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1271
Product name
TWS119
Purity
≥98% (HPLC)
Packaging
25MG
Price
$451
Updated
2023/06/20
Cayman Chemical
Product number
10011251
Product name
TWS119
Purity
≥90%
Packaging
1mg
Price
$37
Updated
2024/03/01
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GSK-3BETA INHIBITOR XII Chemical Properties,Usage,Production

Uses

TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.

Uses

Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.

Definition

ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.

General Description

A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).

Biological Activity

Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Biochem/physiol Actions

TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.

target

GSK-3β

storage

Store at +4°C

References

[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.

GSK-3BETA INHIBITOR XII Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GSK-3BETA INHIBITOR XII manufacturers

Career Henan Chemical Co
Product
GSK-3BETA INHIBITOR XII 601514-19-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

601514-19-6, GSK-3BETA INHIBITOR XIIRelated Search:

IWR-1-endo xav-939 U0126-EtOH 2,6-PYRIDINEDIAMINE, N6-[2-[[4-(2,4-DICHLOROPHENYL)-5-(1H-IMIDAZOL-1-YL)-2-PYRIMIDINYL]AMINO]ETHYL]-3-NITRO- Tideglusib CHIR-99021 1H-Pyrrolo[2,3-d]pyrimidine, 4-methoxy- (8CI,9CI) GSK-3BETA INHIBITOR XII

  • TWS119
  • GSK-3BETA INHIBITOR XII
  • 3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL
  • CS-1924
  • TWS-119; TWS 119
  • CS-445
  • OTAVA-BB 7070707013
  • 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
  • 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
  • TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
  • GSK-3β Inhibitor, TWS119
  • TWS119, >=98%
  • TWS11
  • GSK-3β Inhibitor XII, TWS119
  • TWS 119 (This product is unavailable in the U.S.)
  • TWS S
  • Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
  • GSK-3BETA INHIBITOR XII USP/EP/BP
  • 601514-19-6
  • C18H14N4O22CF3CO2H
  • Akt
  • mTOR
  • PI3K
  • Inhibitors