1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

Product Name: 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
CAS No.: 517918-95-5
Chemical Name: 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
Synonyms: 5-CYANO-7-AZAINDOLE;7-Azaindole-5-carbonitrile;7-Azaindole-5-carbonitrile,97%;5-canyo-1H-Pyrrolo[2,3-b]pyridine;5-Cyano-1H-pyrrolo[2,3-b]pyridine;1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI);1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH;7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
CBNumber: CB2271691
Molecular Formula: C8H5N3
Formula Weight: 143.15
MOL File: 517918-95-5.mol

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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Property

Melting point:: 225.1-225.2°C
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 12.50±0.40(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C8H5N3/c9-4-6-3-7-1-2-10-8(7)11-5-6/h1-3,5H,(H,10,11)
InChIKey: DRAQIXNADYAISI-UHFFFAOYSA-N
SMILES: C12NC=CC1=CC(C#N)=CN=2

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000896
Product name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

TRC

Product number: B529798
Product name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: OR953815
Product name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Purity: 98%
Packaging: 1g
Price: $125
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK322729
Product name: 5-Cyano-7-azaindole
Purity: 98%
Packaging: 1g
Price: $254
Updated: 2021/12/16

ChemScene

Product number: CS-B0100
Product name: 5-canyo-1H-Pyrrolo[2,3-b]pyridine
Purity: 98.53%
Packaging: 5g
Price: $158
Updated: 2021/12/16

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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

Yellow fine crystalline powder

Uses

5-Cyano-7-azaindole is a commonly used intermediate in the synthesis of new anti-tumor drug protease inhibitors, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

557-21-1

183208-35-7

517918-95-5

1. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (5.0 g, 25.0 mmol, 1.0 eq.) and zinc cyanide (3.6 g, 20.0 mmol, 0.8 eq.) were dissolved in anhydrous DMF (65 mL) and deoxygenated for 30 min under argon protection. 2. tetrakis(triphenylphosphine)palladium (1.7 g, 1.5 mmol, 0.06 eq.) was added and the reaction mixture was heated at 80 °C for 36 hours. 3. After completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). 4. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated to dryness under reduced pressure. 5. The residue was treated with a small amount of dichloromethane (CH2Cl2) and the precipitate was collected by filtration. 6. The precipitate was washed with dichloromethane and dried over air to give 1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (Intermediate 2a) as a white solid (3.0 g; yield: 83%; UPLC purity: 100%).

References

[1] Patent: US2018/179199, 2018, A1. Location in patent: Paragraph 0451-0452
[2] Patent: WO2004/78756, 2004, A2. Location in patent: Page 120-121
[3] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 63
[4] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 1425-1427

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Suppliers

China 157 Europe 1 Germany 2 India 4 The Netherlands 1 United Kingdom 2 United States 24 Global 191

P&S Chemicals

Tel: --
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Email: info@pschemicals.com
Country: The Netherlands
ProdList: 2724
Advantage: 58

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE manufacturers

Dideu Industries Group Limited

Product: 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2019-12-25

517918-95-5, 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILERelated Search:

1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile(9CI) 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile(9CI),1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 5-CYANO-6-METHYL-7-AZAINDOLE 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 1-BENZENESULFONYL-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE METHYL 5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-formyl- 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-bromo- 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,4-methoxy-(9CI) 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-bromo- 1H-PYRROLO[3,2-C]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 4-chloro-1-(phenylsulfonyl)- 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-methyl- 5-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI)

5-CYANO-7-AZAINDOLE

5-canyo-1H-Pyrrolo[2,3-b]pyridine

7-Azaindole-5-carbonitrile

7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile

5-Cyano-1H-pyrrolo[2,3-b]pyridine

7-Azaindole-5-carbonitrile,97%

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH

517918-95-5

PYRIDINE

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles

Heterocycle-Pyridine series