1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

Product Name: 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
CAS No.: 827614-66-4
Chemical Name: 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
Synonyms: 1-Isobutyl-4-(4;2-dioxaborolan-2-yl)-1H-pyrazole;1-ISOBUTYL-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Isobutylpyrazole-4-boronic acid pinacol ester 95%;1-ISOBUTYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER;1-Isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1-Isobutylpyrazole-4-boronic acid pinacol ester - [I12067];N-Isobutyltetrahydrothiophene-3-amine-1,1-dioxidehydrochloride;1-(2-methylpropyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1...;1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
CBNumber: CB2272395
Molecular Formula: C13H23BN2O2
Formula Weight: 250.14
MOL File: 827614-66-4.mol

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1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Property

Boiling point:: 248-249 °C(lit.)
Density: 1.003 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4740(lit.)
Flash point:: 118 °F
storage temp.: 2-8°C
pka: 2.07±0.10(Predicted)
form: Liquid
color: Colorless to yellow
CAS DataBase Reference: 827614-66-4

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/38
Safety Statements: 16-26-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
HazardClass: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 642614
Product name: 1-Isobutylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $257
Updated: 2023/01/07

Sigma-Aldrich

Product number: 642614
Product name: 1-Isobutylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $101
Updated: 2022/05/15

TRC

Product number: I786513
Product name: 1-Isobutylpyrazole-4-boronic acid pinacol ester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-D0399
Product name: 1-(2-METHYLPROPYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
Purity: >98.0%
Packaging: 1g
Price: $51
Updated: 2021/12/16

Matrix Scientific

Product number: 113420
Product name: 1-Isobutylpyrazole-4-boronic acid pinacol ester
Packaging: 1g
Price: $111
Updated: 2021/12/16

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1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Chemical Properties,Usage,Production

Uses

1-Isobutylpyrazole-4-boronic acid, pinacol ester

Uses

1-Isobutylpyrazole-4-boronic acid pinacol ester can be used:

In the synthesis of 7-azaindole derivatives as potent PDK1 inhibitors.
As a reactant in the synthesis of imidazo[1,2-a]pyrazine derivatives as potent phosphodiesterase 10A inhibitors.
To prepare 2-substituted-3-aroyl-benzo[b]furan derivatives.

Synthesis

269410-08-4

78-77-3

827614-66-4

To 4-pyrazoleboronic acid pinacol ester (1 g, 5.15 mmol, 1.00 eq.) and isobutyl bromide (1.05 g, 7.66 mmol, 1.49 eq.) in ethyl acetate (60 mL), Cs2CO3 (3.36 g, 10.31 mmol, 2.00 eq.) was added. The reaction mixture was stirred at 80 °C for 4 hours. After completion of the reaction, it was cooled to room temperature and filtered to remove insoluble solids. The filtrate was diluted with ethyl acetate (30 mL) and subsequently washed with brine (40 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum to afford 1-isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.14 g, 88% yield) as a colorless oil.1H-NMR (300 MHz, CDCl3): δ 7.78 (s, 1H), 7.65 (s, 1H), and 3.91 (d, J=7.2Hz, 2H), 2.24-2.19 (m, 1H), 1.32 (s, 12H), 0.90 (d, J=7.2Hz, 6H) ppm. lcms (method D, ESI): rt=1.51min, m/z=251.0[M+H]+.

References

[1] Patent: US2014/288105, 2014, A1. Location in patent: Paragraph 0216-0217
[2] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0277; 0278
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 24, p. 7934 - 7937

1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Suppliers

China 65 Germany 2 India 2 Switzerland 1 United Kingdom 2 United States 13 Global 85

Service Chemical Inc.

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Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

ABCR GmbH & CO. KG

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Email: info@abcr.de
Country: Germany
ProdList: 6831
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View Lastest Price from 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Isobutylpyrazole-4-boronic acid pinacol ester 827614-66-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 827614-66-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-10

827614-66-4, 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLERelated Search:

Boron 1-Methyl-1H-pyrazole-4-boronic acid 1-Methyl-4-pyrazole boronic acid pinacol ester 1-Propyl-1H-pyrazole-4-boronic acid pinacol ester 1H-PYRAZOLE-4-BORONIC ACID 1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 4-Pyrazoleboronic acid pinacol ester 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 1-Isobutyl-1H-pyrazole-4-boronic acid

1-Isobutylpyrazole-4-boronic acid pinacol ester 95%

1-(2-methylpropyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

1-ISOBUTYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

1-ISOBUTYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1-ISOBUTYL-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1-Isobutyl-4-(4

2-dioxaborolan-2-yl)-1H-pyrazole

1H-Pyrazole, 1-(2-Methylpropyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

1-(2-Methylpropyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Isobutyl-pyrazole-4-boronic acid pinacol ester, 1-Isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

N-Isobutyltetrahydrothiophene-3-amine-1,1-dioxidehydrochloride

1-(2-methylpropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1-(2-methylpropyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1...

1-Isobutylpyrazole-4-boronic acid pinacol ester - [I12067]

827614-66-4

C13H23BN2O2

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Heteroaryl Boronate Esters

Organometallic Reagents