1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester

Product Name: 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester
CAS No.: 847818-70-6
Chemical Name: 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester
Synonyms: 1-Eth;1-Ethyl-1H-pyrazole-4-boronic acid, pina;1-Ethylpyrazole-4-boronic Acid Pinacol Ester;1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester;1-ethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester;1-Ethylpyrazole-4-boronic acid pinacol ester - [E10401];1-ethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-p...
CBNumber: CB11486453
Molecular Formula: C11H19BN2O2
Formula Weight: 222.09
MOL File: 847818-70-6.mol

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1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Property

Melting point:: 44-49°C
Boiling point:: 322.6±15.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
refractive index: 1.48
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: clear liquid
pka: 2.11±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C11H19BN2O2/c1-6-14-8-9(7-13-14)12-15-10(2,3)11(4,5)16-12/h7-8H,6H2,1-5H3
InChIKey: UGCRHVPUHAXAAE-UHFFFAOYSA-N
SMILES: N1(CC)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference: 847818-70-6

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706205
Product name: 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 250mg
Price: $40.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 706205
Product name: 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $126
Updated: 2025/07/31

TCI Chemical

Product number: E1348
Product name: 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 1G
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: E1348
Product name: 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 5G
Price: $231
Updated: 2025/07/31

TRC

Product number: E926225
Product name: 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Chemical Properties,Usage,Production

Synthesis

269410-08-4

75-03-6

847818-70-6

To a solution of N,N-dimethylformamide (DMF, 10 mL) of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.0 g, 5.2 mmol) was added cesium carbonate (2.5 g, 7.7 mmol) and ethyl iodide (1.2 mL, 15 mmol). The reaction mixture was stirred at room temperature for 12 hours. After the reaction was completed, the reaction mixture was diluted with water (30 mL). The aqueous phase was extracted with dichloromethane (DCM, 30 mL x 3). The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether (PE)/ethyl acetate (EtOAc) (2:1, v/v) as eluent to afford the colorless oily product 1-ethyl-1H-pyrazole-4-boronic acid pinacol ester (880 mg, 77% yield). Mass spectrometric (MS) analysis (electrospray ionization, cation mode) showed m/z: 223.25 [M + 1]+.

References

[1] Patent: WO2016/615, 2016, A1. Location in patent: Paragraph 00655
[2] Patent: EP1798229, 2007, A1. Location in patent: Page/Page column 130
[3] Patent: US2010/240634, 2010, A1. Location in patent: Page/Page column 67-68
[4] Patent: WO2018/102452, 2018, A2. Location in patent: Paragraph 425; 426
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 19, p. 5299 - 5302

1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Suppliers

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View Lastest Price from 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-10

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