ChemicalBook > CAS DataBase List > 1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

Product Name
1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
CAS No.
864754-18-7
Chemical Name
1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
Synonyms
inoethyL;1-(2-MorphoL;1-(2-Morpholinoethyl)-1H<;1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid;1-(2-Morpholinoethyl)pyrazole-4-boronic Acid Pinacol Ester;1-(2-MORPHOLINOETHYL)-1H-PYRAZOL-4-BORONIC ACID PINACOL ESTER;1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER;4-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyr...;1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid pinacol ester 97%;1-(2-Morpholin-4-ylethyl)-1H-pyrazol-4-ylboronic acid pinacol ester
CBNumber
CB8707033
Molecular Formula
C15H26BN3O3
Formula Weight
307.2
MOL File
864754-18-7.mol
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1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER Property

Melting point:
89-94℃
Boiling point:
440.6±35.0 °C(Predicted)
Density 
1.15±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder
pka
6.71±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36-38
Safety Statements 
26
WGK Germany 
2
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706213
Product name
1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid pinacol ester
Purity
97%
Packaging
250mg
Price
$232
Updated
2025/07/31
Sigma-Aldrich
Product number
706213
Product name
1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$477
Updated
2025/07/31
TRC
Product number
M732775
Product name
1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid pinacol ester
Packaging
500mg
Price
$110
Updated
2021/12/16
Synthonix
Product number
T10045
Product name
4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine
Purity
90+%
Packaging
1g
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
094585
Product name
4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine
Purity
95+%
Packaging
250mg
Price
$213
Updated
2021/12/16
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1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

269410-08-4

3647-69-6

864754-18-7

GENERAL STEPS: N-(2-chloroethyl)morpholine hydrochloride (1.25 g, 6.70 mmol) was added to a solution of anhydrous N,N-dimethylformamide (20 mL) containing pinacol ester of 4-pyrazoleboronic acid (1.00 g, 5.15 mmol) and cesium carbonate (5.54 g, 17.01 mmol) at 0 °C. After stirring for 30 min, the ice water bath was removed. The reaction mixture was continued to be stirred at room temperature for 4 days. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (150 mL) and washed with brine (3 x 100 mL). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by fast column chromatography (Method L7; 12 g silica gel; eluent: ethyl acetate) to afford 1-(2-morpholinylethyl)-1H-pyrazole-4-boronic acid pinacol ester 0.75 g (2.44 mmol, 47% yield). analysis by GC-MS (Method L9) showed R1 = 5.49 min; (no mass detected).1H NMR ( 300 MHz, chloroform-d, method M2) δ 7.80-7.75 (m, 1H), 7.73 (s, 1H), 4.25 (t, J = 6.8 Hz, 2H), 3.73-3.44 (m, 4H), 2.81 (t, J = 6.8 Hz, 2H), 2.50-2.42 (m, 4H), 1.32 (s, 12H).

References

[1] Patent: WO2017/178416, 2017, A1. Location in patent: Page/Page column 116
[2] Patent: WO2010/75270, 2010, A1. Location in patent: Page/Page column 160

1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER Suppliers

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View Lastest Price from 1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER manufacturers

Career Henan Chemical Co
Product
1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER 864754-18-7
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-22

864754-18-7, 1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTERRelated Search:

1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 4-Pyrazoleboronic acid pinacol ester 1-Methyl-1H-pyrazole-4-boronic acid 1H-PYRAZOLE-4-BORONIC ACID 1-Methyl-4-pyrazole boronic acid pinacol ester 1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

  • 1-(2-MORPHOLINOETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
  • 4-(2-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YL]-ETHYL)-MORPHOLINE
  • 1-(2-MORPHOLINOETHYL)-1H-PYRAZOL-4-BORONIC ACID PINACOL ESTER
  • 1-[2-(Morpholin-4-yl)ethyl]-1H-pyrazole-4-boronic acid, pinacol ester
  • 4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine
  • Morpholine, 4-[2-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]-
  • 1-[2-(Morpholin-4-yl)ethyl]-1H-pyrazole-4-boronic acid, pinacol ester 98%
  • 1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid
  • 4-{2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl}Morpholine
  • 1-(2-Morpholinoethyl)-1H-pyrazole-4-boronic acid pinacol ester 97%
  • 1-(2-Morpholinoethyl)pyrazole-4-boronic Acid Pinacol Ester
  • 1-(2-Morpholinoethyl)-1<I>H</I>-pyrazole-4-boronic acid pinacol ester
  • inoethyL
  • 1-(2-MorphoL
  • 4-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyr...
  • 1-(2-Morpholin-4-ylethyl)-1H-pyrazol-4-ylboronic acid pinacol ester
  • 1-(2-Morpholinoethyl)-1<I>H<
  • 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine - [T10045]
  • 864754-18-7
  • C15H26BN3O3
  • Boronate Esters
  • Boronic Acids and Derivatives
  • Chemical Synthesis
  • Heteroaryl Boronate Esters
  • Organometallic Reagents