3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE
- Product Name
- 3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE
- CAS No.
- 864754-21-2
- Chemical Name
- 3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE
- Synonyms
- 1-(3-PyridylMethyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%;1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester;3-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}pyridine;3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE;3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine;Pyridine, 3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-;3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine - [T25839]
- CBNumber
- CB6836681
- Molecular Formula
- C15H20BN3O2
- Formula Weight
- 285.15
- MOL File
- 864754-21-2.mol
3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE Property
- Melting point:
- 102-106℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- BML00215
- Product name
- 1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $427
- Updated
- 2025/07/31
- Product number
- T25839
- Product name
- 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- OR361579
- Product name
- 1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 8H60-1-35
- Product name
- 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 8H60-1-35
- Product name
- 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $292
- Updated
- 2021/12/16
3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE Chemical Properties,Usage,Production
Synthesis
69966-55-8
269410-08-4
864754-21-2
The general procedure for the synthesis of 1-(3-pyridinylmethyl)-1H-pyrazole-4-boronic acid pinacol ester from 3-bromomethylpyridine and 4-pyrazole boronic acid pinacol ester was as follows: 3-bromomethylpyridine (2.67 g, 15.5 mmol) and 4-pyrazole boronic acid pinacol ester (3.01 g, 15.5 mmol) were dissolved in N,N-dimethylformamide (DMF, 20 mL). ) in N,N-dimethylformamide (DMF, 20 mL), followed by addition of potassium carbonate (2.2 g, 16 mmol) to the reaction system. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 8 hours. After completion of the reaction, the mixture was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3), the organic phases were combined and washed with saturated brine (20 mL) and dried over anhydrous sodium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v=1/1.5) to give 280 mg of the target product in the form of light yellow oil in 6.33% yield.
References
[1] Patent: CN106749268, 2017, A. Location in patent: Paragraph 0607; 0608
3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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