1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester
- Product Name
- 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester
- CAS No.
- 847818-70-6
- Chemical Name
- 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester
- Synonyms
- 1-Eth;1-Ethyl-1H-pyrazole-4-boronic acid, pina;1-Ethylpyrazole-4-boronic Acid Pinacol Ester;1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester;1-ethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester;1-Ethylpyrazole-4-boronic acid pinacol ester - [E10401];1-ethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-p...
- CBNumber
- CB11486453
- Molecular Formula
- C11H19BN2O2
- Formula Weight
- 222.09
- MOL File
- 847818-70-6.mol
1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Property
- Melting point:
- 44-49°C
- Boiling point:
- 322.6±15.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- refractive index
- 1.48
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- pka
- 2.11±0.10(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C11H19BN2O2/c1-6-14-8-9(7-13-14)12-15-10(2,3)11(4,5)16-12/h7-8H,6H2,1-5H3
- InChIKey
- UGCRHVPUHAXAAE-UHFFFAOYSA-N
- SMILES
- N1(CC)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
- CAS DataBase Reference
- 847818-70-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 706205
- Product name
- 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40.7
- Updated
- 2025/07/31
- Product number
- 706205
- Product name
- 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- E1348
- Product name
- 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Packaging
- 1G
- Price
- $67
- Updated
- 2025/07/31
- Product number
- E1348
- Product name
- 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Packaging
- 5G
- Price
- $231
- Updated
- 2025/07/31
- Product number
- E926225
- Product name
- 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Chemical Properties,Usage,Production
Synthesis
269410-08-4
75-03-6
847818-70-6
To a solution of N,N-dimethylformamide (DMF, 10 mL) of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.0 g, 5.2 mmol) was added cesium carbonate (2.5 g, 7.7 mmol) and ethyl iodide (1.2 mL, 15 mmol). The reaction mixture was stirred at room temperature for 12 hours. After the reaction was completed, the reaction mixture was diluted with water (30 mL). The aqueous phase was extracted with dichloromethane (DCM, 30 mL x 3). The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether (PE)/ethyl acetate (EtOAc) (2:1, v/v) as eluent to afford the colorless oily product 1-ethyl-1H-pyrazole-4-boronic acid pinacol ester (880 mg, 77% yield). Mass spectrometric (MS) analysis (electrospray ionization, cation mode) showed m/z: 223.25 [M + 1]+.
References
[1] Patent: WO2016/615, 2016, A1. Location in patent: Paragraph 00655
[2] Patent: EP1798229, 2007, A1. Location in patent: Page/Page column 130
[3] Patent: US2010/240634, 2010, A1. Location in patent: Page/Page column 67-68
[4] Patent: WO2018/102452, 2018, A2. Location in patent: Paragraph 425; 426
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 19, p. 5299 - 5302
1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
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View Lastest Price from 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester manufacturers
- Product
- 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 847818-70-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-10