LSD1-IN-1

Product Name: LSD1-IN-1
CAS No.: 1431326-61-2
Chemical Name: LSD1-IN-1
Synonyms: CS-1530;RG 6016;ORY-1001;LSD1-IN-1;RG6016) 2HCl;ORY-1001 (RG-6016);ORY-1001 2HCl salt;ORY-1001(LSD1-IN-1);Iadademstat (ORY-1001;ORY-1001 (RG-6016) 2HCl
CBNumber: CB22739120
Molecular Formula: C15H24Cl2N2
Formula Weight: 303.27046
MOL File: 1431326-61-2.mol

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LSD1-IN-1 Property

storage temp.: Store at -20°C
solubility: insoluble in EtOH; ≥23.15 mg/mL in H2O; ≥6.9 mg/mL in DMSO with gentle warming
form: solid
CAS DataBase Reference: 1431326-61-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19136
Product name: ORY-1001
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19136
Product name: ORY-1001
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 19136
Product name: ORY-1001
Purity: ≥98%
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 19136
Product name: ORY-1001
Purity: ≥98%
Packaging: 10mg
Price: $426
Updated: 2024/03/01

TRC

Product number: O671003
Product name: ORY-1001
Packaging: 10mg
Price: $470
Updated: 2021/12/16

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LSD1-IN-1 Chemical Properties,Usage,Production

Description

Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS³⁷⁰). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC₅₀ < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.

Uses

ORY-1001 is a potent LSD1 inhibitor.

in vitro

ory-1001 is an enantiomerically pure kdm1a inhibitor with high selectivity against related fad dependent aminoxidases. ory-1001 does not inhibit non-related histone modifiers, and is clean in a cerep diversity panel. treatment of thp-1 cells with ory-1001, results in a time/dose dependent me2h3k4 accumulation at kdm1a target genes and concomitant induction of differentiation markers [1].

in vivo

daily oral administration of doses < 0.020 mg/kg leads to significantly reduced tumor growth in rodent xenografts. in vivo studies have shown that ory-1001 presents excellent oral bioavailability, target exposure and activity in vivo [1].

IC 50

<20nm

LSD1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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LSD1-IN-1 Suppliers

China 58 India 1 United States 10 Global 69

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

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View Lastest Price from LSD1-IN-1 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: LSD1-IN-1 1431326-61-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Shaanxi Dideu Medichem Co. Ltd

Product: LSD1-IN-1 1431326-61-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-15

1431326-61-2, LSD1-IN-1Related Search:

Indium

rel-N1-[(1R,2S)-2-Phenylcyclopropyl]-1,4-cyclohexanediamine hydrochloride (1:2)

LSD1-IN-1

ORY-1001

ORY-1001 (RG-6016)

RG 6016

ORY-1001 2HCl salt

RG 6016;RG6016;RG-6016;ORY1001;ORY 1001

ORY-1001 trans and cis isomers

rel-N1-[(1R,2S)-2-Phenylcyclopropyl]-1,4-cyclohexanediamine hydrochloride

CS-1530

LSD1-IN-1;ORY1001;ORY 1001

ORY-1001(LSD1-IN-1)

ORY-1001 (RG-6016) 2HCl

Iadademstat (ORY-1001

RG6016) 2HCl

trans-N1-(2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride

Iadademstat (ORY-1001) 2HCl

Iadademstat (mixture of trans and cis isomers dihydrochloride)

RO 7051790 dihydrochloride

1431326-61-2

143126-61-2