2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
- Product Name
- 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
- CAS No.
- 1375465-91-0
- Chemical Name
- 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
- Synonyms
- CS-2244;ACY-738;ACY 738; ACY738;ACY-738, 10 mM in DMSO;ACY738;ACY-738;ACY 738;2-(1-phenylcyclopropylamino)-N-hydroxypyrimidine-5-carboxamide;N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide;N-hydroxy-2-[(1-phenylcyclopropyl)amino]pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]-;2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
- CBNumber
- CB22742795
- Molecular Formula
- C14H14N4O2
- Formula Weight
- 270.29
- MOL File
- 1375465-91-0.mol
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Property
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:32.0(Max Conc. mg/mL);118.39(Max Conc. mM)
- form
- A crystalline solid
- pka
- 7.75±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28282
- Product name
- ACY-738
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 28282
- Product name
- ACY-738
- Packaging
- 25mg
- Price
- $819
- Updated
- 2024/03/01
- Product number
- 28282
- Product name
- ACY-738
- Packaging
- 5mg
- Price
- $239
- Updated
- 2024/03/01
- Product number
- 28282
- Product name
- ACY-738
- Packaging
- 10mg
- Price
- $419
- Updated
- 2024/03/01
- Product number
- CS-5149
- Product name
- ACY-738
- Purity
- 98.75%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Chemical Properties,Usage,Production
Description
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine . It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1874
- Advantage
- 55
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4294
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4569
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 1005
- Advantage
- 55
- Tel
- 792-3901125 13222993784
- Fax
- 0512-62575043
- sales@unite-pharm.com
- Country
- China
- ProdList
- 321
- Advantage
- 56
- Tel
- 021-58088081 Q3252066219
- Fax
- QQ3382968513
- danping@shsendpharm.com
- Country
- China
- ProdList
- 3100
- Advantage
- 55
View Lastest Price from 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide manufacturers
- Product
- 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide 1375465-91-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03