ChemicalBook > CAS DataBase List > N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Product Name
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
CAS No.
1333146-24-9
Chemical Name
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
Synonyms
CS-2064;CS-4936;ILK-IN-1;OSU-T315;GTPL8116;BDBM50353484;CHEMBL1830587;SCHEMBL8536228;OSU-T315 analog;OSU-T315 (OSU-T 315)
CBNumber
CB22743020
Molecular Formula
C30H30F3N5O
Formula Weight
533.59
MOL File
1333146-24-9.mol
More
Less

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Property

Boiling point:
739.2±60.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 10mM
form 
A solid
pka
16.02±0.46(Predicted)
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
5mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
2mg
Price
$180
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573462
Product name
OSU-T315
Purity
>98%
Packaging
100mg
Price
$1133.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573462
Product name
OSU-T315
Purity
>98%
Packaging
250mg
Price
$1802
Updated
2021/12/16
More
Less

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Chemical Properties,Usage,Production

Uses

ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models[1][2].

in vivo

ILK-IN-2 (25-50 mg/kg, oral or intraperitoneal injection, once daily, 2-4 weeks) delays leukemia progression in mice and significantly improves the overall survival rate of mice harboring TCL1 leukemia cells[ 1 ].
ILK-IN-2 (25-50 mg/kg, orally, daily, for 35 days) inhibits the growth of PC-3 xenograft tumors in nude mice[2].

Animal Model:Pharmacokinetic properties of OSU-T315[1]
Dosage:50 mg/kg, daily for 4 weeks; 25 mg/kg, once daily for 2 weeks
Administration:Oral; Intraperitoneal injection (i.p.)
Result:Reduced white blood cell count and prolonged the survival of mice.
Animal Model:PC-3 tumor xenograft mice model[2]
Dosage:25, 50 mg/kg; daily; 35 days
Administration:Oral
Result:Significantly inhibited tumor growth (25 and 50 mg/kg groups inhibited 48% and 62% respectively).
Showed that the phosphorylation of Ser-473-Akt was dose-dependently inhibited, while the phosphorylation of Thr-308-Akt was not affected. At the same time, the phosphorylation levels of GSK3β and MLC and the expression levels of YB-1, HER2 and EGFR also appeared in parallel decline.

IC 50

ILK: 0.6 μM (IC50)

References

[1] Ta-Ming Liu, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. DOI:10.1182/blood-2014-06-583518
[2] Su-Lin Lee, et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. DOI:10.1021/jm2007744

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Suppliers

China 60 United States 10 Global 70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1333146-24-9, N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamideRelated Search:


  • N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
  • ILK-IN-1
  • BDBM50353484
  • CHEMBL1830587
  • CS-4936
  • GTPL8116
  • SCHEMBL8536228
  • OSU-T315
  • CS-2064
  • 1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-
  • ILK-IN-2 (CPD 22: OSU-T315 analog)
  • N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4-(trifluorometh
  • Integrin,inhibit,ILK IN 2,ILKIN2,Inhibitor
  • OSU-T315 analog
  • ILK-IN-2, 10 mM in DMSO
  • OSU-T315 (OSU-T 315)
  • 1333146-24-9
  • C30H30F3N5O