ChemicalBook > CAS DataBase List > (S)-1-(2-FLUOROPHENYL)ETHANOL

(S)-1-(2-FLUOROPHENYL)ETHANOL

Product Name
(S)-1-(2-FLUOROPHENYL)ETHANOL
CAS No.
171032-87-4
Chemical Name
(S)-1-(2-FLUOROPHENYL)ETHANOL
Synonyms
S-OF-PEL;(S)-1-(2-FLUOROPHENYL)ETHANOL;(S)-2'-Fluorophenylethan-1-ol;(S)-1-(o-Fluorophenyl)ethanol;(S)-1-(2-Ffluorophenyl)ethanol;(1S)-1-(2-Fluorophenyl)ethanol;(1S)-1-(2-Fluorophenyl)ethan-1-ol;(S)-2-Fluoro-alpha-methylbenzyl alcohol;Benzenemethanol,2-fluoro-a-methyl-, (aS)-;Benzenemethanol, 2-fluoro-α-methyl-, (αS)-
CBNumber
CB2274384
Molecular Formula
C8H9FO
Formula Weight
140.15
MOL File
171032-87-4.mol
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(S)-1-(2-FLUOROPHENYL)ETHANOL Property

Boiling point:
193℃
Density 
1.123
Flash point:
88℃
storage temp. 
Sealed in dry,Room Temperature
pka
13.95±0.20(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F593623
Product name
(S)​-​1-​(2-​Fluorophenyl)​ethanol
Packaging
50mg
Price
$90
Updated
2021/12/16
TRC
Product number
F593623
Product name
(S)​-​1-​(2-​Fluorophenyl)​ethanol
Packaging
250mg
Price
$275
Updated
2021/12/16
Apolloscientific
Product number
PC0605
Product name
(1S)-1-(2-Fluorophenyl)ethan-1-ol
Packaging
1g
Price
$435
Updated
2021/12/16
SynQuest Laboratories
Product number
2602-3-S2
Product name
(S)-1-(2-Fluorophenyl)ethanol
Purity
97%
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0014718
Product name
(S)-1-(2-FLUOROPHENYL)ETHANOL
Purity
95.00%
Packaging
250MG
Price
$721.88
Updated
2021/12/16
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(S)-1-(2-FLUOROPHENYL)ETHANOL Chemical Properties,Usage,Production

Uses

(S)?-?1-?(2-?Fluorophenyl)?ethanol is a building block used in organic synthesis such as JN403, a novel nicotinic acetylcholine receptor α7 agonist.

Synthesis

445-27-2

171032-87-4

General procedure for the synthesis of (S)-1-(2-fluorophenyl)ethanol from o-fluoroacetophenone: (R)-methyloxazole borane (0.32 g, 1.2 mmol) was dissolved in tert-butanol (60 mL) under the protection of nitrogen, N,N-diethylanilinoborane (2.6 g, 16 mmol) was added followed by a slow, titrative addition of 1-(2-fluorophenyl)ethanone at 45 °C ( 2.0 g, 14 mmol) in tert-butanol solution (150 mL) and the reaction mixture was stirred. After 1 hour of reaction, the mixture was cooled to room temperature, methanol was added and concentrated. To the concentrate, 1.0 N hydrochloric acid was added and extracted with ethyl acetate, the organic layer was washed with saturated brine and dried with anhydrous sodium sulfate sequentially, and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane to hexane/ethyl acetate=85/15) to afford the title compound (S)-1-(2-fluorophenyl)ethanol (1.9 g, 92% yield) as a colorless liquid.1H-NMR (400 MHz, CDCl3) δ: 1.52 (3H, d, J=6.8 Hz), 5.17-5.24 (1H, m ), 6.98-7.05 (1H, m), 7.15 (1H, ddd, J=1.2, 7.6, 7.6 Hz), 7.21-7.28 (1H, m), 7.49 (1H, ddd, J=1.6, 7.6, 7.6 Hz).

References

[1] Journal of the American Chemical Society, 1998, vol. 120, # 51, p. 13529 - 13530
[2] Tetrahedron: Asymmetry, 2003, vol. 14, # 6, p. 710 - 716
[3] Patent: US2018/162868, 2018, A1. Location in patent: Paragraph 1572-1573
[4] Tetrahedron Asymmetry, 2002, vol. 13, # 13, p. 1347 - 1349
[5] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4619 - 4622

(S)-1-(2-FLUOROPHENYL)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-1-(2-FLUOROPHENYL)ETHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(1S)-1-(2-Fluorophenyl)ethanol 171032-87-4
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
(S)-1-(2-FLUOROPHENYL)ETHANOL 171032-87-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-02

171032-87-4, (S)-1-(2-FLUOROPHENYL)ETHANOLRelated Search:

Ravuconazole Voriconazole (R)-2-FLUOROMANDELIC ACID Posaconazole Fluconazole SAPERCONAZOLE 2-(4-FLUOROPHENYL)ETHANOL,2-(P-FLUOROPHENYL)ETHANOL 1-(3-FLUOROPHENYL)ETHANOL,1-(3-Fluorophenyl)ethanol, 98.5%,1-(3-Fluorophenyl)ethanol,97% (R)-2-CHLORO-1-(4-FLUOROPHENYL)ETHANOL 2-(3-FLUOROPHENYL)ETHANOL,2-(M-FLUOROPHENYL)ETHANOL 2-(O-FLUOROPHENYL)ETHANOL,2-(2-fluorophenyl)ethanol (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol (R)-1-(4-FLUOROPHENYL)ETHANOL,(R)-(+)-1-(4-FLUOROPHENYL)ETHANOL 2-(3-CHLORO-4-FLUOROPHENYL)ETHANOL 1-(4-Fluorophenyl)ethanol, 4-Fluorophenylmethylcarbinol,1-(P-FLUOROPHENYL)ETHANOL,1-(4-FLUOROPHENYL)ETHANOL (S)-1-(4-Fluorophenyl)ethanol 98%,(S)-1-(4-Fluorophenyl)ethanol98%,(S)-(-)-1-(4-FLUOROPHENYL)ETHANOL,(S)-1-(4-FLUOROPHENYL)ETHANOL 1-(2-FLUOROPHENYL)ETHANOL,1-(2'-FLUOROPHENYL)ETHANOL,1-(M-FLUOROPHENYL)ETHANOL (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

  • (S)-2'-Fluorophenylethan-1-ol
  • (1S)-1-(2-Fluorophenyl)ethan-1-ol
  • (S)-2-Fluoro-alpha-methylbenzyl alcohol
  • (S)-1-(2-FLUOROPHENYL)ETHANOL
  • S-OF-PEL
  • (1S)-1-(2-Fluorophenyl)ethanol
  • (alphaS)-2-Fluoro-alpha-methylbenzenemethanol
  • (S)-1-(o-Fluorophenyl)ethanol
  • Benzenemethanol,2-fluoro-a-methyl-, (aS)-
  • Benzenemethanol, 2-fluoro-alpha-methyl-, (alphaS)- (9CI)
  • (S)-1-(2-Ffluorophenyl)ethanol
  • Benzenemethanol, 2-fluoro-α-methyl-, (αS)-
  • 171032-87-4
  • HALIDE
  • Alcohols, Hydroxy Esters and Derivatives
  • Chiral Compounds