3-Fluorophenethyl alcohol
- Product Name
- 3-Fluorophenethyl alcohol
- CAS No.
- 52059-53-7
- Chemical Name
- 3-Fluorophenethyl alcohol
- Synonyms
- Pratraxa impurity 1;3-Fluorobenzeneethanol;3-Fluorophenylethanol ;3-fluorophenyl alcohol;3-FLUOROPHENETHYL ALCOHOL;2-(M-FLUOROPHENYL)ETHANOL;2-(3-FLUOROPHENYL)ETHANOL;3-Fluorophenethylealcohol;Benzeneethanol, 3-fluoro-;2-(3-Fluorophenyl)ethan-1-ol
- CBNumber
- CB7491498
- Molecular Formula
- C8H9FO
- Formula Weight
- 140.15
- MOL File
- 52059-53-7.mol
3-Fluorophenethyl alcohol Property
- Boiling point:
- 90 °C/3 mmHg (lit.)
- Density
- 1.125 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.509(lit.)
- Flash point:
- 225 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 14.76±0.10(Predicted)
- color
- Clear colorless
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 36/37/38-21/22-34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- 2810
- WGK Germany
- 3
- HS Code
- 29062990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F0776
- Product name
- 2-(3-Fluorophenyl)ethanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- F0776
- Product name
- 2-(3-Fluorophenyl)ethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- F632318
- Product name
- 2-(3-Fluorophenyl)ethanol
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC5701
- Product name
- 3-Fluorophenethyl alcohol
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 2601-3-Y1
- Product name
- 3-Fluorophenethyl alcohol
- Purity
- 98%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
3-Fluorophenethyl alcohol Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
General Description
3-Fluorophenethyl alcohol is a fluorinated β-phenethyl alcohol. Regioselective synthesis of 3-fluorophenethyl alcohol via regioselective hydroboration has been reported.
Synthesis
331-25-9
52059-53-7
The general procedure for the synthesis of 3-fluorophenylethanol from 3-fluorophenylacetic acid was as follows: to a stirred solution of 3-fluorophenylacetic acid (5.0 g, 32.0 mmol) in ether (100 ml) was slowly added dropwise an ether solution of lithium aluminum hydroxide (32.4 ml, 1 M, 32.4 mmol) at -10 °C. The reaction mixture was gradually warmed to 25°C and stirred continuously for 1 hour. Subsequently, the reaction mixture was cooled again to -10°C and the reaction was quenched by sequential addition of methanol (20 ml) and 4M sodium hydroxide solution (20 ml). The resulting slurry was filtered and the filtrate was concentrated by evaporation under vacuum. The crude product was purified by silica gel column chromatography using CH2Cl2/MeOH/NH3 (80:8:1) as eluent to give 3-fluorophenylethanol (3.80 g, 84% yield) finally. The product was confirmed by NMR hydrogen spectrum (250 MHz, CDCl3): δ 2.87 (3H, t, J = 6.5 Hz, CH2), 3.87 (3H, t, J = 6.5 Hz, CH2), 6.89-7.02 (3H, m, Ar-H), 7.23-7.33 (1H, m, Ar-H).
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 14, p. 5528 - 5535
[2] Tetrahedron Asymmetry, 2001, vol. 12, # 4, p. 585 - 596
[3] Patent: US5889008, 1999, A
[4] Helvetica Chimica Acta, 1973, vol. 56, p. 2460 - 2479
[5] Journal of the American Chemical Society, 1978, vol. 100, p. 228 - 246
3-Fluorophenethyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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