3-Fluorophenylacetic acid
- Product Name
- 3-Fluorophenylacetic acid
- CAS No.
- 331-25-9
- Chemical Name
- 3-Fluorophenylacetic acid
- Synonyms
- 2-(3-Fluorophenyl)acetic Acid;RARECHEM AL BO 0121;3-Fluorophenylacetic;3-Fluorophenlacetic acid;3-fluoro-benzeneaceticaci;M-FLUOROPHENYLACETIC ACID;3-FLUOROPHENYLACETIC ACID;Between the fluorine acid;3-fluoro-benzeneacetic acid;3-Fluorophenylaceticacid98%
- CBNumber
- CB2691734
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 331-25-9.mol
3-Fluorophenylacetic acid Property
- Melting point:
- 42-44 °C (lit.)
- Boiling point:
- 151 °C
- Density
- 1.1850 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.10±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Slightly soluble in chloroform and methanol. Insoluble in water.
- BRN
- 775898
- InChI
- InChI=1S/C8H7FO2/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4H,5H2,(H,10,11)
- InChIKey
- YEAUYVGUXSZCFI-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=CC(F)=C1
- CAS DataBase Reference
- 331-25-9(CAS DataBase Reference)
- NIST Chemistry Reference
- M-fluorophenylacetic acid(331-25-9)
- EPA Substance Registry System
- Benzeneacetic acid, 3-fluoro- (331-25-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 38-36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- TSCA
- TSCA listed
- HazardClass
- IRRITANT
- HS Code
- 29163900
- Storage Class
- 13 - Non Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 248045
- Product name
- 3-Fluorophenylacetic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $74.6
- Updated
- 2023/06/20
- Product number
- F0216
- Product name
- 3-Fluorophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- F0216
- Product name
- 3-Fluorophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- F621370
- Product name
- 3-Fluorophenylacetic acid
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC4130
- Product name
- 3-Fluorophenylacetic acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $51
- Updated
- 2021/12/16
3-Fluorophenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow or light beige crystalline
Uses
3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries. It is also used as a medicine intermediates.
Uses
3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries.
Synthesis
Preparation of m-fluorophenylacetic acid: 350 g of 32% HCl and 250 g of 3-fluoroaniline were added to the reaction flask, heated and stirred until dissolved clear. Cool down to -5 to 5 ??, 20 g tetramethyl ammonium chloride and 20 g copper chloride. Acetone solution containing 300 g of vinylidene chloride was added dropwise. Maintaining the temperature, slowly add dropwise a solution containing 230 g of isopropyl nitrite and 200 g of acetone. Hold the reaction for 2 hours. The reaction was completed and quenched. Dichloromethane was added and extracted and distilled and collected to give 1-(2,2,2-trichloroethyl)-3-fluorobenzene 398 g. A three-necked flask was protected with nitrogen and 500 g of water and 60 g of p-toluenesulfonic acid were added. Heated to 80-95??C. 300g of intermediate 1-(2,2,2-trichloroethyl)-3-fluorobenzene was added dropwise. Dropwise addition was completed and the reaction was held for 8 hours. The reaction was completed. The system was quenched by adding dropwise to ice water at reduced temperature. Filtered, washed with water, dried and recrystallized with dichloroethane to obtain the pure m-fluorophenylacetic acid 151.2 g, HPLC purity greater than 99 wt%.
3-Fluorophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluorophenylacetic acid manufacturers
- Product
- 3-Fluorophenylacetic acid 331-25-9
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1Kg/Drum
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2020-08-21
- Product
- 3-Fluorophenylacetic acid 331-25-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-25
- Product
- 3-Fluorophenylacetic acid 331-25-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31