DIETHYL 2-FLUORO-2-METHYL-MALONATE

Product Name: DIETHYL 2-FLUORO-2-METHYL-MALONATE
CAS No.: 16519-02-1
Chemical Name: DIETHYL 2-FLUORO-2-METHYL-MALONATE
Synonyms: 131916;DIETHYL 2-FLUORO-2-METHYL-MALONATE;diethyl 2-fluoro-2-methylpropanedioate;Propanedioic acid,2-fluoro-2-methyl-, 1,3-diethyl ester
CBNumber: CB2274546
Molecular Formula: C8H13FO4
Formula Weight: 192.18
MOL File: 16519-02-1.mol

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DIETHYL 2-FLUORO-2-METHYL-MALONATE Property

Boiling point:: 74-75°C 7mm
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

Risk Statements: 34-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 1760

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 128263
Product name: Diethyl2-fluoro-2-methylmalonate
Purity: 98%
Packaging: 1g
Price: $451
Updated: 2021/12/16

AK Scientific

Product number: 5302AD
Product name: Diethyl2-fluoro-2-methylmalonate
Packaging: 10g
Price: $938
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0314459
Product name: DIETHYL-2-FLUORO-2-METHYL-MALONATE
Purity: 98.00%
Packaging: 10G
Price: $1891.89
Updated: 2021/12/16

Ambeed

Product number: A739666
Product name: Diethyl2-fluoro-2-methylmalonate
Purity: 95+%
Packaging: 25g
Price: $1285
Updated: 2021/12/16

Crysdot

Product number: CD13021068
Product name: Diethyl2-fluoro-2-methylmalonate
Purity: 95+%
Packaging: 10g
Price: $653
Updated: 2021/12/16

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DIETHYL 2-FLUORO-2-METHYL-MALONATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 109, p. 7194, 1987 DOI: 10.1021/ja00257a051

Synthesis

609-08-5

16519-02-1

In a test tube fitted with a stir bar, N-fluorobis(methylsulfonyl)imide (38.2 mg, 0.2 mmol) and 1,2-dichloroethane (1.0 mL) were added and stirred at room temperature until completely dissolved. Subsequently, diethyl 2-methylmalonate (17.4 mg, 0.1 mmol) and tetraisopropoxy prototitanate (0.016 mL, 0.05 mmol) were added to this solution and the reaction was carried out for 12 hours at room temperature. After completion of the reaction, water was added, extracted with dichloromethane (3 times), the organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was analyzed by 19F-NMR and the yield of the target product diethyl 2-fluoro-2-methylmalonate was quantified using hexafluorobenzene as an internal standard. Finally, the product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane = 10/90, v/v) to afford the purified diethyl 2-fluoro-2-methylmalonate (7) as a colorless and transparent liquid (18.7 mg, 0.097 mmol, 97% yield).

References

[1] Patent: JP2016/23178, 2016, A. Location in patent: Paragraph 0031-0033
[2] Green Chemistry, 2016, vol. 18, # 7, p. 1864 - 1868
[3] Patent: WO2017/49069, 2017, A1. Location in patent: Paragraph 00160
[4] Journal of the American Chemical Society, 1984, vol. 106, # 2, p. 452 - 454
[5] Canadian Journal of Chemistry, 1965, vol. 43, p. 1700 - 1713

DIETHYL 2-FLUORO-2-METHYL-MALONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIETHYL 2-FLUORO-2-METHYL-MALONATE Suppliers

China 18 Germany 1 United Kingdom 1 United States 6 Global 26

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
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ProdList: 63687
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Aladdin Scientific

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Synthonix Inc

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Matrix Scientific

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3B Scientific Corporation

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3B Scientific Corporation

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16519-02-1, DIETHYL 2-FLUORO-2-METHYL-MALONATERelated Search:

Dimethyl fluoromalonate DIETHYL 2-FLUORO-2-METHYL-MALONATE 2-FLUOROISOBUTYRIC ACID METHYL 2-FLUORO-2-METHYLPROPIONATE Diethyl fluoromalonate 2-FLUORO-2-METHANESULFONYLOXYMETHYL-MALONIC ACID DIETHYL ESTER 2-FLUORO-2-PHENYLMALONIC ACID, DIETHYL ESTER

131916

Propanedioic acid,2-fluoro-2-methyl-, 1,3-diethyl ester

DIETHYL 2-FLUORO-2-METHYL-MALONATE

diethyl 2-fluoro-2-methylpropanedioate

16519-02-1

C8H13FO4

Aliphatics

Esters