4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid
- Product Name
- 4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid
- CAS No.
- 139262-76-3
- Chemical Name
- 4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid
- Synonyms
- H2L5186303;H2L5186303 >=98% (HPLC);4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid;(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid;(2Z,2′Z)-4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid;2-Butenoic acid, 4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-, (Z,Z)- (9CI)
- CBNumber
- CB22750709
- Molecular Formula
- C26H20N2O8
- Formula Weight
- 488.45
- MOL File
- 139262-76-3.mol
4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble25mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0989
- Product name
- H2L5186303
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 14663
- Product name
- H2L5186303
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 14663
- Product name
- H2L5186303
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 14663
- Product name
- H2L5186303
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $126
- Updated
- 2024/03/01
- Product number
- 14663
- Product name
- H2L5186303
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $523
- Updated
- 2023/06/20
4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid Chemical Properties,Usage,Production
Description
H2L5186303 (139262-76-3) is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist.? IC50?= 8.9 nM, 1230 nM and 27.35 μM for LPA2, LPA3, and LPA1 respectively.1,2
Uses
H2L5186303 is an antidepressant acting on the LPA1 (lysophosphatidic acid receptor 1) and induce insulin-like growth factor-I receptor transactivation as well as causing enhanced cell proliferation.
Biochem/physiol Actions
H2L5186303 is specific antagonist of the lysophosphatidic acid receptor LPA2 (Ki = 7.2 nM). The compound H2L5186303 displays 40- to 1800-fold selectivity over other LPA receptors.
storage
Store at +4°C
References
1) Fells?et al. (2008)?Identification of non-lipid LPA3 antagonists by virtual screening; Bioorg. Med. Chem.?16?6207 2) Fells?et al. (2009)?Structure-based drug design identifies novel LPA3 antagonists; Bioorg. Med. Chem. 17?7457