MK-886

Product Name: MK-886
CAS No.: 118414-82-7
Chemical Name: MK-886
Synonyms: MK866;MK-886;CS-1988;L-663,536;CGS-81585;MK-886 (Base);MK 886 - Bio-X ?;MK-886 (L-663,536);MK-886 (Free Base);MK-886, 10 mM in DMSO
CBNumber: CB8671381
Molecular Formula: C27H34ClNO2S
Formula Weight: 472.08
MOL File: 118414-82-7.mol

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MK-886 Property

Melting point:: 295-297°C
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 32 mg/mL
form: White solid.
color: white
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey: CBNCIYNCWVGEKJ-UHFFFAOYSA-M
SMILES: N1(CC2=CC=C(Cl)C=C2)C(CC(C)(C)C([O-])=O)=C(SC(C)(C)C)C2C=C(C(C)C)C=CC1=2.[Na+]

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 475889
Product name: MK-886 - CAS 118414-82-7 - Calbiochem
Packaging: 5MG
Price: $177
Updated: 2025/07/31

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

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MK-886 Chemical Properties,Usage,Production

Description

MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3

Chemical Properties

White Solid

Uses

Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.

Uses

MK-886 is a potent and selective inhibitor of FLAP and Cox-1.

Definition

ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.

Biological Activity

An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .

storage

Store at RT

References

[1] J GILLARD. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.[J]. Canadian journal of physiology and pharmacology, 1989, 67 5: 456-464. DOI:10.1139/y89-073
[2] J F EVANS. 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.[J]. Molecular Pharmacology, 1991, 40 1: 22-27.
[3] JAMES P. KEHRER. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.[J]. The Ukrainian Biochemical Journal, 2001, 78 1: 899-906. DOI:10.1042/0264-6021:3560899

MK-886 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-886 Suppliers

Canada 1 China 136 Europe 1 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 19 Global 166

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 860
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3057
Advantage: 60

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View Lastest Price from MK-886 manufacturers

Career Henan Chemical Co

Product: MK-886 118414-82-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

118414-82-7, MK-886Related Search:

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Fatostatin A JNJ 1661010 NAGLY MK-886,MK 886 SODIUM SALT,mk-886 sodium hydrate,MK-886 hydrate sodium salt MK-886

L-663,536

CS-1988

1-[(4-CHLOROPHENYL)METHYL]-3-[(1,1-DIMETHYLETHYL)THIO]-ALPHA,ALPHA-DIMETHYL-5-(1-METHYLETHYL)-1H-INDOLE-2-PROPANOIC ACID

MK-886

3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt

3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid

3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid

3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid

CGS-81585

3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid

1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-

1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid

MK-886 (Free Base)

MK-886 (L-663,536)

3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid

MK866

1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-

leukotriene,FLAP,5-LOX,5-LO activating protein,non-competitive,L-663536,L663536,keratin-1,Leukotriene Receptor,Inhibitor,biosynthesis,Peroxisome proliferator-activated receptors,PPAR,PPARα,Apoptosis,MK 886,MK-886,inhibit

MK-886 (Base)

MK886, Lipoxygenase inhibitor

MK-886, 10 mM in DMSO

MK 886 - Bio-X ?

118414-82-7

C27H34ClNO2S

All Inhibitors

Inhibitors

Prostanoid receptor and related