MK-886
- Product Name
- MK-886
- CAS No.
- 118414-82-7
- Chemical Name
- MK-886
- Synonyms
- MK866;MK-886;CS-1988;L-663,536;CGS-81585;MK-886 (Base);MK-886 (L-663,536);MK-886 (Free Base);3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid;3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
- CBNumber
- CB8671381
- Molecular Formula
- C27H34ClNO2S
- Formula Weight
- 472.08
- MOL File
- 118414-82-7.mol
MK-886 Property
- Melting point:
- 295-297°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: 32 mg/mL
- form
- White solid.
- color
- white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 475889
- Product name
- MK-886 - CAS 118414-82-7 - Calbiochem
- Packaging
- 5MG
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 21753
- Product name
- MK-886
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 21753
- Product name
- MK-886
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 21753
- Product name
- MK-886
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 21753
- Product name
- MK-886
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $330
- Updated
- 2024/03/01
MK-886 Chemical Properties,Usage,Production
Description
MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3
Chemical Properties
White Solid
Uses
Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.
Uses
MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
Definition
ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.
Biological Activity
An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .
storage
Store at RT
References
References/Citations 1) Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor; Can. .J. Physiol .Pharmacol. 67 456 2) Evans et al (1991) 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors; Mol. Pharmacol. 40 22 3) Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886; Biochem. J. 356 899
MK-886 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MK-886 manufacturers
- Product
- MK-886 118414-82-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23