ChemicalBook > CAS DataBase List > MK-886

MK-886

Product Name
MK-886
CAS No.
118414-82-7
Chemical Name
MK-886
Synonyms
MK866;MK-886;CS-1988;L-663,536;CGS-81585;MK-886 (Base);MK-886 (L-663,536);MK-886 (Free Base);MK886, Lipoxygenase inhibitor;3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
CBNumber
CB8671381
Molecular Formula
C27H34ClNO2S
Formula Weight
472.08
MOL File
118414-82-7.mol
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MK-886 Property

Melting point:
295-297°C
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: 32 mg/mL
form 
White solid.
color 
white
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
475889
Product name
MK-886 - CAS 118414-82-7 - Calbiochem
Packaging
5MG
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
21753
Product name
MK-886
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
21753
Product name
MK-886
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
21753
Product name
MK-886
Purity
≥98%
Packaging
10mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
21753
Product name
MK-886
Purity
≥98%
Packaging
25mg
Price
$330
Updated
2024/03/01
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MK-886 Chemical Properties,Usage,Production

Description

MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3

Chemical Properties

White Solid

Uses

Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.

Uses

MK-886 is a potent and selective inhibitor of FLAP and Cox-1.

Definition

ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.

Biological Activity

An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .

storage

Store at RT

References

References/Citations 1) Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor; Can. .J. Physiol .Pharmacol. 67 456 2) Evans et al (1991) 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors; Mol. Pharmacol. 40 22 3) Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886; Biochem. J. 356 899

MK-886 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-886 Suppliers

Canada 1 China 109 Europe 1 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 19 Global 139
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View Lastest Price from MK-886 manufacturers

Career Henan Chemical Co
Product
MK-886 118414-82-7
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

118414-82-7, MK-886Related Search:

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Fatostatin A JNJ 1661010 NAGLY MK-886,MK 886 SODIUM SALT,mk-886 sodium hydrate,MK-886 hydrate sodium salt MK-886

  • L-663,536
  • CS-1988
  • 1-[(4-CHLOROPHENYL)METHYL]-3-[(1,1-DIMETHYLETHYL)THIO]-ALPHA,ALPHA-DIMETHYL-5-(1-METHYLETHYL)-1H-INDOLE-2-PROPANOIC ACID
  • MK-886
  • 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt
  • 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid
  • 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
  • 3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
  • CGS-81585
  • 3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
  • 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
  • 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
  • 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid
  • MK-886 (Free Base)
  • MK-886 (L-663,536)
  • 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
  • MK866
  • 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
  • leukotriene,FLAP,5-LOX,5-LO activating protein,non-competitive,L-663536,L663536,keratin-1,Leukotriene Receptor,Inhibitor,biosynthesis,Peroxisome proliferator-activated receptors,PPAR,PPARα,Apoptosis,MK 886,MK-886,inhibit
  • MK-886 (Base)
  • MK886, Lipoxygenase inhibitor
  • 118414-82-7
  • C27H34ClNO2S
  • All Inhibitors
  • Inhibitors
  • Prostanoid receptor and related