CK-0157869
- Product Name
- CK-0157869
- CAS No.
- 388592-44-7
- Chemical Name
- CK-0157869
- Synonyms
- CK 869;CK-869;CS-2870;CK-0157869;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one;4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-;CK869,Arp2/3 Complex,inhibit,CK-869,Inhibitor,CK 869,Actin-related protein 2/3 complex
- CBNumber
- CB22755865
- Molecular Formula
- C17H16BrNO3S
- Formula Weight
- 394.28
- MOL File
- 388592-44-7.mol
CK-0157869 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- white to light gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- C9124
- Product name
- CK-869
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- C9124
- Product name
- CK-869
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $379
- Updated
- 2024/03/01
- Product number
- 15251
- Product name
- CK 869
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 15251
- Product name
- CK 869
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 15251
- Product name
- CK 869
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $186
- Updated
- 2024/03/01
CK-0157869 Chemical Properties,Usage,Production
Description
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
Uses
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
Uses
CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.