CK-0157869

ChemicalBook > CAS DataBase List > CK-0157869

Product Name: CK-0157869
CAS No.: 388592-44-7
Chemical Name: CK-0157869
Synonyms: CK 869;CK-869;CS-2870;CK-0157869;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one;4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-;CK869,Arp2/3 Complex,inhibit,CK-869,Inhibitor,CK 869,Actin-related protein 2/3 complex
CBNumber: CB22755865
Molecular Formula: C17H16BrNO3S
Formula Weight: 394.28
MOL File: 388592-44-7.mol

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CK-0157869 Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to light gray

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9124
Product name: CK-869
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: C9124
Product name: CK-869
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $379
Updated: 2024/03/01

Cayman Chemical

Product number: 15251
Product name: CK 869
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 15251
Product name: CK 869
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 15251
Product name: CK 869
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

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CK-0157869 Chemical Properties,Usage,Production

Description

CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC₅₀ value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.

Uses

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
to induce membrane blebbing in HT1080 fibrosarcoma cells
to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Uses

CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-0157869 Preparation Products And Raw materials

Raw materials

Preparation Products

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CK-0157869 Suppliers

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Sigma-Aldrich

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388592-44-7, CK-0157869Related Search:

CK-636

2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone

CK 869

CK-0157869

CK-869

CS-2870

CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869

4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-

CK869,Arp2/3 Complex,inhibit,CK-869,Inhibitor,CK 869,Actin-related protein 2/3 complex

2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one

388592-44-7