BOC-D-LYS(Z)-OH

Product Name: BOC-D-LYS(Z)-OH
CAS No.: 55878-47-2
Chemical Name: BOC-D-LYS(Z)-OH
Synonyms: N6-((Benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-D-lysine;NSC 334941;BOC-D-LYSINE(CBZ);BOC-D-LYSINE(Z)-OH;Nα-Boc-Nε-Z-D-lysine;N2-Boc-N6-Cbz-D-lysine;BOC-N-EPSILON-Z-D-LYSINE;Nalpha-Boc-Nepsilon-Z-D-lysine;Nα-Boc-Nε-Z-D-lysine≥ 98% (HPLC);(Tert-Butoxy)Carbonyl D-Lys(Z)-OH
CBNumber: CB2295150
Molecular Formula: C19H28N2O6
Formula Weight: 380.44
MOL File: 55878-47-2.mol

More

Less

BOC-D-LYS(Z)-OH Property

Boiling point:: 587.0±50.0 °C(Predicted)
Density: 1.176±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.99±0.21(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 264801
Product name: N-alpha-Boc-Nε-Z-D-lysine
Packaging: 5g
Price: $373
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47734
Product name: N-alpha-Boc-Nepsilon-Z-D-lysine
Packaging: 50g
Price: $513
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47734
Product name: N-alpha-Boc-Nepsilon-Z-D-lysine
Packaging: 25g
Price: $320.5
Updated: 2021/12/16

Chem-Impex

Product number: 03536
Product name: Nα-Boc-Nε-Z-D-lysine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $16.8
Updated: 2021/12/16

Chem-Impex

Product number: 03536
Product name: Nα-Boc-Nε-Z-D-lysine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $33.6
Updated: 2021/12/16

More

Less

BOC-D-LYS(Z)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

106719-44-2

501-53-1

55878-47-2

General procedure for the synthesis of (R)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid from N-(tert-butoxycarbonyl)-D-lysine and benzyl chloroformate: to an aqueous solution of 1 M NaOH (37 mL), N-(tert-butoxycarbonyl)-D-lysine (3.00 g, 12.2 mmol) was added at room temperature, then slowly dioxane was added until the suspension was completely dissolved. Subsequently, benzyl chloroformate (2.70 g, 15.9 mmol) was added dropwise over 30 min at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the dioxane was removed by distillation under reduced pressure. The reaction mixture was acidified to pH 2 with 1 M HCl at 0 °C. The aqueous layer was extracted with EtOAc and the combined organic layers were dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the target compound 29 (4.4 g, 11.6 mmol, 95% yield) as a white foamy solid, which did not require further purification. 1H-NMR (360 MHz, CDCl3): δ (ppm) 7.37-7.23 (m, 5H), 6.18 (br s, 1H), 5.17-4.86 (m, 3H), 4.83 (s, 1H), 4.22-4.04 (m, 1H), 3.13-3.11 (m, 2H), 1.76-1.37 (m, 15H ). 13C-NMR (150 MHz, CDCl3): δ (ppm) 176.4 (CO), 156.8 (CO), 156.0 (CO), 136.6 (Cq), 128.7 (2 × CH), 128.3 (2 × CH), 128.1 (CH), 80.4 (Cq), 66.9 (CH2), 53.3 (CH). 40.7 (CH2), 32.0 (CH2), 29.3 (CH2), 29.5 (3×CH3), 22.1 (CH2). MS (ESI) m/z (%): (C14H20N2O4) 222 (14), (C7H12NO4) 174 (12), 128 (32), 108 (27), 92 (11), (C7H7) 91 (100), 84 (20), 57 (52), 41 (20). MS (ESI) m/z calculated value C14H20N2O4 [M+H-C5H9O2]+, 280.14; measured value, 280.14. LC-MS (ESI) m/z calculated value C19H28N2O6Na [M+Na]+, 403.2; measured value, 403.7. HPLC purity, 96%, tR = 19.7min, Gradient A.

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 2222 - 2243
[2] Patent: WO2017/63910, 2017, A1. Location in patent: Page/Page column 38-39

BOC-D-LYS(Z)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BOC-D-LYS(Z)-OH Suppliers

China 48 India 1 United Kingdom 1 United States 3 Global 53

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
Fax: qq1405432731
Email: sales@chempharmatech.com
Country: China
ProdList: 915
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
ProdList: 8258
Advantage: 55

Wuxi Asia Peptide Biotechnology Limited Company

Tel: 0510-83583050 13771062561
Fax: 0510-83583039
Email: willsun@peptide-search.com
Country: China
ProdList: 6716
Advantage: 58

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

More

Less

View Lastest Price from BOC-D-LYS(Z)-OH manufacturers

Career Henan Chemical Co

Product: BOC-D-LYS(Z)-OH 55878-47-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-17

55878-47-2, BOC-D-LYS(Z)-OHRelated Search:

D-Lysine 6-(Z-AMINO)-1-HEXANOL N-Boc-cadaverine BOC-D-LYS-OH D(-)-Norvaline BOC-D-Alanine BOC-D-ABU-OH BOC-D-NLE-OH 2-N-BOC-6-N-CBZ-D-LYSINOL D-Norleucine N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine N-Benzyloxycarbonyl-6-aminohexanoic acid BOC-D-LYS(Z)-OH BOC-D-NVA-OH N-CARBOBENZOXY-1,5-DIAMINOPENTANE HYDROCHLORIDE H-D-LYS(Z)-OH BOC-D-LYS(Z)-OH N-BOC-DL-2-AMINO-1-HEXANOL 90

BOC-N-EPSILON-Z-D-LYSINE

BOC-D-LYSINE(CBZ)

BOC-D-LYSINE(Z)-OH

N-ALPHA-BUTOXYCARBONYL-N-EPSILON-CARBOBENZOXY-D-LYSINE

N-ALPHA-BOC-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE

N2-[(1,1-Dimethylethoxy)Carbonyl]-N6-[(Phenylmethoxy)Carbonyl]-D-Lysine

Nalpha-Boc-Nepsilon-Z-D-lysine

NSC 334941

(R)-6-(((Benzyloxy)carbonyl)amino)-2-(((tert-butoxy)carbonyl)amino)-hexanoic acid

Nα-Boc-Nε-Z-D-lysine≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl D-Lys(Z)-OH

N-ALPHA-BOC-N-EPSILON-CBZ-D-LYSINE

(2R)-6-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}hexanoic acid

D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-

Nα-Boc-Nε-Z-D-lysine

2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoic acid

N6-((Benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-D-lysine

N2-Boc-N6-Cbz-D-lysine

55878-47-2