ChemicalBook > CAS DataBase List > BOC-D-LYS(Z)-OH

BOC-D-LYS(Z)-OH

Product Name: BOC-D-LYS(Z)-OH
CAS No.: 55878-47-2
Chemical Name: BOC-D-LYS(Z)-OH
Synonyms: N6-((Benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-D-lysine;NSC 334941;BOC-D-LYSINE(CBZ);BOC-D-LYSINE(Z)-OH;Nα-Boc-Nε-Z-D-lysine;N2-Boc-N6-Cbz-D-lysine;BOC-N-EPSILON-Z-D-LYSINE;Nalpha-Boc-Nepsilon-Z-D-lysine;Nα-Boc-Nε-Z-D-lysine≥ 98% (HPLC);(Tert-Butoxy)Carbonyl D-Lys(Z)-OH
CBNumber: CB2295150
Molecular Formula: C19H28N2O6
Formula Weight: 380.44
MOL File: 55878-47-2.mol

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BOC-D-LYS(Z)-OH Property

Boiling point:: 587.0±50.0 °C(Predicted)
Density: 1.176±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.99±0.21(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 264801
Product name: N-alpha-Boc-Nε-Z-D-lysine
Packaging: 5g
Price: $373
Updated: 2021/12/16

Chem-Impex

Product number: 03536
Product name: Nα-Boc-Nε-Z-D-lysine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $16.8
Updated: 2021/12/16

Chem-Impex

Product number: 03536
Product name: Nα-Boc-Nε-Z-D-lysine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $33.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47734
Product name: N-alpha-Boc-Nepsilon-Z-D-lysine
Packaging: 5G
Price: $88.5
Updated: 2021/12/16

Chem-Impex

Product number: 03536
Product name: Nα-Boc-Nε-Z-D-lysine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 25G
Price: $117.6
Updated: 2021/12/16

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BOC-D-LYS(Z)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

106719-44-2

501-53-1

55878-47-2

General procedure for the synthesis of (R)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid from N-(tert-butoxycarbonyl)-D-lysine and benzyl chloroformate: to an aqueous solution of 1 M NaOH (37 mL), N-(tert-butoxycarbonyl)-D-lysine (3.00 g, 12.2 mmol) was added at room temperature, then slowly dioxane was added until the suspension was completely dissolved. Subsequently, benzyl chloroformate (2.70 g, 15.9 mmol) was added dropwise over 30 min at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the dioxane was removed by distillation under reduced pressure. The reaction mixture was acidified to pH 2 with 1 M HCl at 0 °C. The aqueous layer was extracted with EtOAc and the combined organic layers were dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the target compound 29 (4.4 g, 11.6 mmol, 95% yield) as a white foamy solid, which did not require further purification. 1H-NMR (360 MHz, CDCl3): δ (ppm) 7.37-7.23 (m, 5H), 6.18 (br s, 1H), 5.17-4.86 (m, 3H), 4.83 (s, 1H), 4.22-4.04 (m, 1H), 3.13-3.11 (m, 2H), 1.76-1.37 (m, 15H ). 13C-NMR (150 MHz, CDCl3): δ (ppm) 176.4 (CO), 156.8 (CO), 156.0 (CO), 136.6 (Cq), 128.7 (2 × CH), 128.3 (2 × CH), 128.1 (CH), 80.4 (Cq), 66.9 (CH2), 53.3 (CH). 40.7 (CH2), 32.0 (CH2), 29.3 (CH2), 29.5 (3×CH3), 22.1 (CH2). MS (ESI) m/z (%): (C14H20N2O4) 222 (14), (C7H12NO4) 174 (12), 128 (32), 108 (27), 92 (11), (C7H7) 91 (100), 84 (20), 57 (52), 41 (20). MS (ESI) m/z calculated value C14H20N2O4 [M+H-C5H9O2]+, 280.14; measured value, 280.14. LC-MS (ESI) m/z calculated value C19H28N2O6Na [M+Na]+, 403.2; measured value, 403.7. HPLC purity, 96%, tR = 19.7min, Gradient A.

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 2222 - 2243
[2] Patent: WO2017/63910, 2017, A1. Location in patent: Page/Page column 38-39

BOC-D-LYS(Z)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-D-LYS(Z)-OH manufacturers

Career Henan Chemical Co

Product: BOC-D-LYS(Z)-OH 55878-47-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-17

55878-47-2, BOC-D-LYS(Z)-OHRelated Search:

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BOC-N-EPSILON-Z-D-LYSINE

BOC-D-LYSINE(CBZ)

BOC-D-LYSINE(Z)-OH

N-ALPHA-BUTOXYCARBONYL-N-EPSILON-CARBOBENZOXY-D-LYSINE

N-ALPHA-BOC-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE

N2-[(1,1-Dimethylethoxy)Carbonyl]-N6-[(Phenylmethoxy)Carbonyl]-D-Lysine

Nalpha-Boc-Nepsilon-Z-D-lysine

NSC 334941

(R)-6-(((Benzyloxy)carbonyl)amino)-2-(((tert-butoxy)carbonyl)amino)-hexanoic acid

Nα-Boc-Nε-Z-D-lysine≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl D-Lys(Z)-OH

N-ALPHA-BOC-N-EPSILON-CBZ-D-LYSINE

(2R)-6-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}hexanoic acid

D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-

Nα-Boc-Nε-Z-D-lysine

2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoic acid

N6-((Benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-D-lysine

N2-Boc-N6-Cbz-D-lysine

55878-47-2